Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 4/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10745596 | 0.81 | L3MBTL1 (0.49) | KCNQ3KCNQ2CFTRALDH1A1HPGD | |
| SCHEMBL10927262 | 0.80 | CFTR (0.48) | KCNQ3KCNQ2CFTRHSD11B1ALDH1A1 | |
| SCHEMBL11773094 | 0.79 | RAB9A (0.49) | CFTRALDH1A1CYP3A4HPGDCYP2C19 | |
| SCHEMBL11703013 | 0.77 | KCNQ3 (0.53) | KCNQ3KCNQ2CFTRALDH1A1HPGD | |
| SCHEMBL10743702 | 0.76 | CFTR (0.44) | KCNQ3KCNQ2CFTRALDH1A1CYP3A4 | |
| SCHEMBL10741661 | 0.75 | MAPT (0.53) | CFTRALDH1A1CYP3A4CYP2C9HPGD | |
| SCHEMBL10744540 | 0.74 | CFTR (0.47) | CFTRALDH1A1CYP3A4CYP2C9HPGD | |
| SCHEMBL10747092 | 0.73 | CFTR (0.48) | CFTRALDH1A1CYP3A4CYP2C9HPGD | |
| SCHEMBL4440220 | 0.73 | CFTR (0.54) | CFTRALDH1A1HPGDMRGPRX4KDM4E | |
| SCHEMBL10741387 | 0.73 | L3MBTL1 (0.47) | CFTRALDH1A1CYP3A4CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4621091-A | 5-LIPOXYGENASE INHIBITORS; USEFUL IN TREATMENT OF INFLAMMATION, PAIN AND FEVER | MERCK & CO., INC. (US) | 1986-11-04 | — | — | US | disclosed |
| EP-0177927-A1 | 3-Hydroxybenzo[b]thiophene-2-sulfide derivatives as specific-5-lipoxygenase inhibitors | MERCK & CO. INC. (US) | 1986-04-16 | — | — | EP | disclosed |