Dimethylamine

Dimethylamine

SCHEMBL10845320

CNC.Cc1cc(C(C)C)c(N)c(C(C)C)c1

nearest known ligand 0.45

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Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 4/20 0.39
NOS3 P29474 3/20 0.39
NOS1 P29475 3/20 0.39
ALDH1A1 P00352 2/20 0.38
TSHR P16473 1/20 0.38
TRPA1 O75762 1/20 0.35
LMNA P02545 1/20 0.35
CHRM1 P11229 1/20 0.35
SLC6A2 P23975 1/20 0.35
ADRA1A P35348 1/20 0.35
HTR2B P41595 1/20 0.35
POLB P06746 1/20 0.34
GAA P10253 1/20 0.34
GFER P55789 1/20 0.34
KDM4E B2RXH2 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2735032 0.93 NOS2 (0.43) NOS2NOS3NOS1ALDH1A1TSHR
SCHEMBL27808479 0.81 KDM4E (0.42) NOS2NOS3NOS1ALDH1A1TSHR
SCHEMBL4549115 0.79 TSHR (0.35) NOS2NOS3NOS1ALDH1A1TSHR
SCHEMBL31145750 0.77 NOS3 (0.36) NOS2NOS3NOS1ALDH1A1TSHR
SCHEMBL19506010 0.76 GAA (0.35) ALDH1A1LMNAPOLBGAAGFER
SCHEMBL31553481 0.74 TACR1 (0.35) ALDH1A1LMNACHRM1SLC6A2ADRA1A
SCHEMBL20706615 0.74 HTT (0.37) NOS2NOS3NOS1ALDH1A1TSHR
SCHEMBL2155116 0.74 ALDH1A1 (0.38) ALDH1A1TSHRTRPA1LMNACHRM1
SCHEMBL461449 0.74 CA1 (0.55) NOS2NOS3NOS1ALDH1A1TSHR
SCHEMBL101727 0.73 DHFR (0.41) ALDH1A1TSHRPOLBGAAGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4568744-A ANTIBACTERICIDES AND DIRUETIC INTERMEDIATES BURROUGHS WELLCOME CO. (US) 1986-02-04 US disclosed