Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 4/20 | 0.34 |
| ▸ | NOS3 | P29474 | 3/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11415140 | 0.94 | TSHR (0.39) | TSHRNOS2NOS3NOS1ALDH1A1 | |
| SCHEMBL2735032 | 0.85 | NOS2 (0.43) | TSHRNOS2NOS3NOS1ALDH1A1 | |
| SCHEMBL30692102 | 0.84 | KDM4E (0.37) | TSHRNOS2NOS3NOS1ALDH1A1 | |
| SCHEMBL19507086 | 0.82 | GABRA1 (0.45) | TSHRALDH1A1GAAUSP2PKM | |
| SCHEMBL20180215 | 0.82 | GABRA1 (0.45) | TSHRALDH1A1GAAUSP2PKM | |
| SCHEMBL15756301 | 0.79 | USP2 (0.44) | TSHRALDH1A1GAAUSP2PKM | |
| Dimethylamine SCHEMBL10845320 | 0.79 | NOS2 (0.39) | TSHRNOS2NOS3NOS1ALDH1A1 | |
| SCHEMBL560581 | 0.77 | TSHR (0.39) | TSHRALDH1A1GAAUSP2PKM | |
| SCHEMBL20706615 | 0.76 | HTT (0.37) | TSHRNOS2NOS3NOS1ALDH1A1 | |
| SCHEMBL4549116 | 0.76 | CA1 (0.50) | TSHRGAAHPGDRORCTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4233916-A1 | COMPLEX, AND USE THEREOF | RIKEN (JP) | 2023-08-30 | — | — | EP | disclosed |
| US-20130217783-A1 | Therapeutic Compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8350097-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120196939-A1 | Therapeutic Compounds | SOWOOD HEALTHCARE LLC | 2012-08-02 | — | — | US | disclosed |
| US-8173849-B2 | Therapeutic compounds | SIGNATURE THERAPEUTICS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100249246-A1 | Therapeutic Compounds | PHARMACOFORE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217783-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | TSHR 1530/4885NOS2 2874/4885NOS3 3220/4885 |
| US-20100249246-A1 | Therapeutic Compounds | OPRM1, OGFR, UGT1A1 | TSHR 1530/4885NOS2 2874/4885NOS3 3220/4885 |
| US-20120196939-A1 | Therapeutic Compounds | OPRM1, OPRD1, SCN1B | TSHR 1877/4885NOS2 2475/4885NOS3 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.