Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1085243 | 0.76 | SLC6A3 (0.45) | SLC6A3SLC6A2SLC6A4DHFR | |
| SCHEMBL1420772 | 0.76 | SLC6A3 (0.45) | SLC6A3SLC6A2SLC6A4DHFR | |
| SCHEMBL1719101 | 0.75 | MGLL (0.39) | MBTD1 | |
| SCHEMBL1719489 | 0.73 | ADAMTS7 (0.40) | MBTD1 | |
| SCHEMBL1085180 | 0.69 | CHRNB2 (0.52) | MBTD1L3MBTL3L3MBTL4L3MBTL1 | |
| SCHEMBL31536263 | 0.66 | HPGD (0.54) | — | |
| SCHEMBL1085278 | 0.64 | L3MBTL3 (0.65) | MBTD1L3MBTL3L3MBTL4L3MBTL1 | |
| SCHEMBL31536222 | 0.64 | HPGD (0.59) | — | |
| SCHEMBL28806235 | 0.64 | TSHR (0.55) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL14382903 | 0.64 | SLC6A3 (0.42) | SLC6A3SLC6A2SLC6A4DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153805-B2 | Biaryl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-04-10 | — | — | US | disclosed |