Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083695 | 1.00 | ALDH1A1 (0.38) | ALDH1A1HPGDMAP3K7TAB1HCRTR1 | |
| SCHEMBL1085435 | 0.89 | CHRNB2 (0.42) | ALDH1A1HPGDHCRTR1HCRTR2KDM4E | |
| SCHEMBL1085607 | 0.89 | TRPV1 (0.46) | ALDH1A1TRPV1MEN1KMT2ASPHK2 | |
| SCHEMBL1083712 | 0.89 | TRPV1 (0.46) | ALDH1A1TRPV1MEN1KMT2ASPHK2 | |
| SCHEMBL1083708 | 0.88 | CCR5 (0.42) | MAP3K7TAB1HCRTR1HCRTR2CCR5 | |
| SCHEMBL1085077 | 0.88 | CCR5 (0.42) | MAP3K7TAB1HCRTR1HCRTR2CCR5 | |
| SCHEMBL1083727 | 0.86 | L3MBTL3 (0.43) | SLC6A7DGAT2HSD11B1MGLL | |
| SCHEMBL1083744 | 0.85 | MAPK7 (0.41) | MAP3K7TAB1HCRTR1HCRTR2SLC6A7 | |
| SCHEMBL1085088 | 0.85 | MAPK7 (0.41) | MAP3K7TAB1HCRTR1HCRTR2SLC6A7 | |
| SCHEMBL1719267 | 0.82 | MAP3K7 (0.38) | MAP3K7TAB1HCRTR1HCRTR2SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153805-B2 | Biaryl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090048238-A1 | NOVEL BIARYL DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048238-A1 | NOVEL BIARYL DERIVATIVES | CCR3, CCRL2, CCR2 | ALDH1A1 1202/4885HPGD 2707/4885MAP3K7 2217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.