Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10853163 | 0.96 | POLB (0.76) | POLBALDH1A1EPHX2FPR2RAB9A | |
| SCHEMBL10756515 | 0.90 | POLB (0.70) | POLBALDH1A1EPHX2FPR2RAB9A | |
| SCHEMBL10753428 | 0.86 | POLB (0.76) | POLBALDH1A1EPHX2FPR2RAB9A | |
| SCHEMBL10857079 | 0.78 | RAB9A (0.57) | ALDH1A1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL10857089 | 0.77 | RAB9A (0.54) | POLBALDH1A1FPR2RAB9AMEN1 | |
| SCHEMBL9903230 | 0.75 | ALDH1A1 (0.54) | POLBALDH1A1EPHX2 | |
| SCHEMBL22659944 | 0.75 | POLB (0.75) | POLBALDH1A1EPHX2RAB9AMEN1 | |
| SCHEMBL10855620 | 0.75 | CDK2 (0.56) | POLBALDH1A1FPR2RAB9AMEN1 | |
| SCHEMBL10857581 | 0.75 | RAB9A (0.54) | POLBALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL9902657 | 0.74 | ALDH1A1 (0.52) | POLBALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4565826-A | HYPOTENSIVE, CARDIONASCULAR, ANTIULCER, ANTISECRETORY, GASTROINTESTINAL DISORDERS | WILLIAM H. RORER, INC. (US) | 1986-01-21 | — | — | US | disclosed |
| US-4436911-A | HYPOTENSIVE, ANTISPASMODIC, ANTIULCER, ANTIPARASITIC | WILLIAM H. RORER, INC. (US) | 1984-03-13 | — | — | US | disclosed |