Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13445906 | 0.81 | LMNA (0.53) | HTTLMNAKDM4EEPHX2POLB | |
| SCHEMBL10856293 | 0.80 | RAB9A (0.59) | HTTLMNARAB9ANPC1TSHR | |
| Hydrochloric Acid SCHEMBL11053107 | 0.79 | RAB9A (0.57) | HTTLMNARAB9ANPC1TSHR | |
| SCHEMBL23566413 | 0.76 | LMNA (0.56) | HTTLMNAKDM4EEPHX2RAB9A | |
| SCHEMBL10857203 | 0.74 | MDM2 (0.60) | LMNAKDM4ERAB9APOLBALDH1A1 | |
| SCHEMBL10857049 | 0.73 | EPHX2 (0.46) | EPHX2FFAR2 | |
| SCHEMBL10858052 | 0.73 | FFAR2 (0.40) | KDM4EALDH1A1FFAR2 | |
| SCHEMBL11238734 | 0.73 | SMN1; SMN2 (0.57) | KDM4EEPHX2RAB9ANPC1TSHR | |
| SCHEMBL10854874 | 0.72 | KDM4E (0.46) | KDM4ERAB9ANPC1POLBTDP1 | |
| SCHEMBL10857079 | 0.72 | RAB9A (0.57) | HTTLMNAKDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4565826-A | HYPOTENSIVE, CARDIONASCULAR, ANTIULCER, ANTISECRETORY, GASTROINTESTINAL DISORDERS | WILLIAM H. RORER, INC. (US) | 1986-01-21 | — | — | US | disclosed |
| US-4436911-A | HYPOTENSIVE, ANTISPASMODIC, ANTIULCER, ANTIPARASITIC | WILLIAM H. RORER, INC. (US) | 1984-03-13 | — | — | US | disclosed |