SCHEMBL10858693

SCHEMBL10858693

CC(=O)Nc1ccc(S(=O)(=O)N2C(O)c3ccccc3C2O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.59
MEN1 O00255 5/20 0.58
KMT2A Q03164 5/20 0.58
MAPT P10636 2/20 0.52
USP2 O75604 2/20 0.52
LMNA P02545 2/20 0.52
TSHR P16473 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
L3MBTL1 Q9Y468 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CA12 O43570 1/20 0.50
CA9 Q16790 1/20 0.50
IDO1 P14902 1/20 0.49
MMP1 P03956 1/20 0.49
MMP2 P08253 1/20 0.49
MMP9 P14780 1/20 0.49
MMP8 P22894 1/20 0.49
MMP13 P45452 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9326548 0.79 ACHE (0.50) LMNANPSR1CA1CA2MMP2
SCHEMBL11165160 0.78 ACHE (0.49) POLBKMT2ALMNATSHRL3MBTL1
SCHEMBL10856085 0.75 MMP2 (0.46) MEN1KMT2AMAPTLMNAL3MBTL1
SCHEMBL9275284 0.75 CA1 (0.62) POLBMEN1KMT2AMAPTUSP2
SCHEMBL30513336 0.74 MEN1 (0.61) POLBMEN1KMT2AMAPTUSP2
SCHEMBL11162173 0.74 HSD11B1 (0.37) TSHRCA1CA2CA12CA9
SCHEMBL10851027 0.72 ACHE (0.52) KMT2AMAPTCA1CA2CA12
SCHEMBL14534640 0.72 PKM (0.74) POLBMEN1KMT2AMAPTLMNA
SCHEMBL15178963 0.71 KMT2A (0.62) POLBMEN1KMT2AMAPTUSP2
SCHEMBL1792654 0.71 KMT2A (0.64) POLBMEN1KMT2AMAPTUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4596876-A Isoindoline compounds EASTMAN KODAK COMPANY (US) 1986-06-24 US claimed
EP-0067714-A2 Phthalaldehyde adduct and image-forming compositions incorporating the same EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-12-22 EP claimed
US-4596876-A Isoindoline compounds EASTMAN KODAK COMPANY (US) 1986-06-24 US disclosed
US-4410623-A COBALT (III) COMPLEX WITH AMINE LIGAND EASTMAN KODAK COMPANY (US) 1983-10-18 US disclosed
EP-0067714-A2 Phthalaldehyde adduct and image-forming compositions incorporating the same EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-12-22 EP disclosed