SCHEMBL1086015

SCHEMBL1086015

NC(=O)C=Cc1cccs1

nearest known ligand 0.71

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.71
ABCG2 Q9UNQ0 2/20 0.59
SMN1; SMN2 Q16637 6/20 0.57
ALDH1A1 P00352 3/20 0.57
MAPT P10636 3/20 0.57
LMNA P02545 2/20 0.57
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
KDM4E B2RXH2 2/20 0.54
MEN1 O00255 1/20 0.54
PSMD14 O00487 1/20 0.54
TP53 P04637 1/20 0.54
GLA P06280 1/20 0.54
HTT P42858 1/20 0.54
KMT2A Q03164 1/20 0.54
HPGD P15428 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4197243 1.00 HCAR2 (0.71) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL5598744 0.85 HCAR2 (0.74) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL5598741 0.85 HCAR2 (0.74) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL600082 0.83 HCAR2 (1.00) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL143282 0.83 HCAR2 (1.00) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL3707176 0.83
SCHEMBL1862223 0.82 HCAR2 (0.69) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL3382206 0.82 HCAR2 (0.69) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL20273260 0.82 HCAR2 (0.69) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT
SCHEMBL369705 0.82 HCAR2 (0.69) HCAR2ABCG2SMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103232429-A Preparation method of (E)-N-[3-(methylamino)propyl]-3-(thiophene-2-yl) acrylamide and salt thereof Shaoxing minsheng pharmaceutical co ltd 2013-08-07 CN claimed
JP-4828407-B2 2011-11-30 JP claimed
EP-2209765-A2 HISTONE DEACETYLASE INHIBITORS Orchid Research Laboratories Limited (IN) 2010-07-28 EP claimed
WO-2009053808-A2 HISTONE DEACETYLASE INHIBITORS ORCHID RESEARCH LABORATORIES LIMITED (IN) 2009-04-30 WO claimed
EP-1594869-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF Targacept, Inc. (US) 2005-11-16 EP claimed
WO-2004076449-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF TARGACEPT, INC. (US) 2004-09-10 WO claimed
US-3945831-A Photosensitive resins containing a thienylacrylic acid ester or amide group FUJI PHOTO FILM CO., LTD. (JA) 1976-03-23 US claimed
CN-118974066-A EGFR degrading agent 北京泰德制药股份有限公司 2024-11-15 CN disclosed
EP-4415561-A2 ORGANIC COMPOUNDS Givaudan SA (CH) 2024-08-21 EP disclosed
WO-2024141787-A2 A HYDROGEL BEAD-BASED PLATFORM FOR THE HIGH THROUGHPUT SCREENING OF IMMUNOMODULATORY PEPTIDES AND DESIGNER PEPTIDES FOR DENDRITIC CELLS/MACROPHAGE REPROGRAMMING THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2024-07-04 WO disclosed
CN-115737682-B Engineering exosome targeted slow release system for osteoarthritis treatment and preparation method and application thereof 四川大学 2023-12-29 CN disclosed
WO-2023198180-A1 EGFR DEGRADATION AGENT 北京泰德制药股份有限公司 2023-10-19 WO disclosed
WO-2023062110-A2 ORGANIC COMPOUNDS GIVAUDAN SA (CH) 2023-04-20 WO disclosed
EP-1594869-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF Targacept, Inc. (US) 2005-11-16 EP disclosed
WO-2005023331-A2 HYDROGEL NANOCOMPSITES FOR OPHTHALMIC APPLICATIONS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) 2005-03-17 WO disclosed
WO-2004076449-A2 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF TARGACEPT, INC. (US) 2004-09-10 WO disclosed
EP-1252891-A1 REMEDIES OR PREVENTIVES FOR LIVER DISEASES CONTAINING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES ISHIHARA SANGYO KAISHA, LTD. (JP) 2002-10-30 EP disclosed
WO-1998042347-A1 PHARMACEUTICAL COMPOSITION CONTAINING A PHOSPHORYLAMIDE AND AN AYNTIBIOTIC TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-01 WO disclosed
CN-1058396-A Diaminotrifluoromethderivatives derivatives and preparation method thereof and the phospholipase A that contains them 2Inhibitor ISHIHARA SANGYO KAISHA (JP) 1992-02-05 CN disclosed
US-4012377-A ANTIMICROBIAL, PARASITICIDES GLAXO LABORATORIES LIMITED (EN) 1977-03-15 US disclosed