SCHEMBL5598741

SCHEMBL5598741

O=C(/C=C/c1cccs1)/C=C/c1cccs1

nearest known ligand 0.74

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.74
SMN1; SMN2 Q16637 5/20 0.64
ALDH1A1 P00352 3/20 0.64
ABCG2 Q9UNQ0 2/20 0.61
LMNA P02545 3/20 0.59
MAPT P10636 3/20 0.59
RAB9A P51151 3/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
KDM4E B2RXH2 2/20 0.56
NPC1 O15118 2/20 0.56
PSMD14 O00487 1/20 0.56
TP53 P04637 1/20 0.56
GLA P06280 1/20 0.56
HTT P42858 1/20 0.56
HPGD P15428 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5598744 1.00 HCAR2 (0.74) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL12425740 0.91 HCAR2 (0.62) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL9329482 0.89 HCAR2 (0.66) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL9329490 0.89 HCAR2 (0.66) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL29242546 0.88 HCAR2 (0.65) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL28357180 0.86 ABCG2 (0.65) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL1086015 0.85 HCAR2 (0.71) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL143282 0.85 HCAR2 (1.00) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL4197243 0.85 HCAR2 (0.71) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA
SCHEMBL600082 0.85 HCAR2 (1.00) HCAR2SMN1; SMN2ALDH1A1ABCG2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230378534-A1 CYCLIC SULFONE ADDITIVES FOR LITHIUM ION BATTERIES NOHMs Technologies, Inc. 2023-11-23 US disclosed
US-20230378534-A1 CYCLIC SULFONE ADDITIVES FOR LITHIUM ION BATTERIES NOHMs Technologies, Inc. 2023-11-23 US disclosed
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2022-05-19 US disclosed
WO-2022071987-A1 CYCLIC SULFONE ADDITIVES FOR LITHIUM ION BATTERIES NOHMs Technologies, Inc. (US) 2022-04-07 WO disclosed
US-20200383958-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2020-12-10 US disclosed
US-10751330-B2 Human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2020-08-25 US disclosed
US-10744124-B2 Human therapeutic agents ANKH LIFE SCIENCES LIMITED (IE) 2020-08-18 US disclosed
US-20200147061-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2020-05-14 US disclosed
EP-3275465-B1 THERAPEUTIC COMPOSITIONS COMPRISING A COMBINATION OF A HARMINE AND ISOVANILLIN COMPONENT ANKH LIFE SCIENCES LTD (IE) 2020-05-06 EP disclosed
US-10576067-B2 Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof ANKH LIFE SCIENCES LIMITED (IE) 2020-03-03 US disclosed
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES STC.UNM 2015-01-08 US disclosed
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES STC.UNM 2015-01-08 US disclosed
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES STC.UNM 2015-01-08 US disclosed
US-8841326-B2 Therapeutic curcumin derivatives STC.UNM (US) 2014-09-23 US disclosed
US-8841326-B2 Therapeutic curcumin derivatives STC.UNM (US) 2014-09-23 US disclosed
US-8841326-B2 Therapeutic curcumin derivatives STC.UNM (US) 2014-09-23 US disclosed
US-20070060644-A1 Therapeutic curcumin derivatives STC.UNM 2007-03-15 US disclosed
US-20070060644-A1 Therapeutic curcumin derivatives STC.UNM 2007-03-15 US disclosed
US-20070060644-A1 Therapeutic curcumin derivatives STC.UNM 2007-03-15 US disclosed
US-20060276536-A1 Cancer treatment using curcumin derivatives STC.UNM 2006-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10744124-B2 Human therapeutic agents INMT, HNMT, HASPIN HCAR2 219/4885SMN1; SMN2 2552/4885ALDH1A1 371/4885
US-20070060644-A1 Therapeutic curcumin derivatives FABP2, GLS2, FABP1 HCAR2 414/4885SMN1; SMN2 88/4885ALDH1A1 670/4885
US-10751330-B2 Human therapeutic agents INMT, HNMT, HASPIN HCAR2 219/4885SMN1; SMN2 2552/4885ALDH1A1 371/4885
US-20230378534-A1 CYCLIC SULFONE ADDITIVES FOR LITHIUM ION BATTERIES NCS1, TST, NDUFS8 HCAR2 4753/4885SMN1; SMN2 394/4885ALDH1A1 2902/4885
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES FABP2, GLS2, FABP1 HCAR2 414/4885SMN1; SMN2 88/4885ALDH1A1 670/4885
US-20220152001-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN HCAR2 219/4885SMN1; SMN2 2552/4885ALDH1A1 371/4885
US-20200147061-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN HCAR2 219/4885SMN1; SMN2 2552/4885ALDH1A1 371/4885
US-20200383958-A1 HUMAN THERAPEUTIC AGENTS INMT, HNMT, HASPIN HCAR2 219/4885SMN1; SMN2 2552/4885ALDH1A1 371/4885
US-10576067-B2 Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof INMT, HNMT, COMT HCAR2 332/4885SMN1; SMN2 3053/4885ALDH1A1 320/4885
US-20060276536-A1 Cancer treatment using curcumin derivatives BRCA1, VHL, TP53 HCAR2 679/4885SMN1; SMN2 3797/4885ALDH1A1 110/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.