SCHEMBL10865232

SCHEMBL10865232

CCC(Br)c1ccc(OC)c(OC)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.51
PPARD Q03181 1/20 0.51
PPARA Q07869 1/20 0.51
CA2 P00918 3/20 0.45
ALDH1A1 P00352 2/20 0.44
LMNA P02545 2/20 0.44
TP53 P04637 1/20 0.44
MAPT P10636 1/20 0.44
ALOX12 P18054 1/20 0.44
ACHE P22303 4/20 0.44
CA1 P00915 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
CA12 O43570 1/20 0.43
CA7 P43166 1/20 0.43
CA9 Q16790 1/20 0.43
CA14 Q9ULX7 1/20 0.43
KMT2A Q03164 2/20 0.43
CYP2C19 P33261 2/20 0.43
GAA P10253 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10415398 0.98 PPARG (0.50) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL7182938 0.82 PPARG (0.53) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL3884192 0.81 PPARG (0.52) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL13872003 0.79 PPARG (0.55) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL4438129 0.79 ACHE (0.50) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL12844553 0.79 PPARG (0.55) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL18596510 0.78 PPARG (0.54) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL8298141 0.78 ALDH1A1 (0.60) PPARGPPARDPPARACA2ALDH1A1
SCHEMBL7752210 0.78 PTGS2 (0.52) MAPTACHEL3MBTL1CA9KMT2A
SCHEMBL27710622 0.78 PPARG (0.58) PPARGPPARDPPARACA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1059436-C Benzazepine * -, benzoxazepine * -, and benzothiazepine * -N-acetic acid derivatives SOLVAY PHARM GMBH (DE) 2000-12-13 CN disclosed
CN-1147506-A Benzonitrogen * -benzooxynitrin * -and benzothiepin * -N-acetic acid derivatives KALI CHEMIE PHARMA GMBH (DE) 1997-04-16 CN disclosed
EP-0180399-A2 Anti-tumor 4-Hydroxy-2-cyclopentenones TEIJIN LIMITED (JP) 1986-05-07 EP disclosed