Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438129 | 0.84 | ACHE (0.50) | PPARGPPARDPPARAL3MBTL1CYP2C19 | |
| SCHEMBL27710622 | 0.83 | PPARG (0.58) | PPARGPPARDPPARAL3MBTL1CYP2C19 | |
| SCHEMBL5592068 | 0.83 | SLC6A2 (0.48) | PPARGPPARDPPARAL3MBTL1CYP2C19 | |
| SCHEMBL13955907 | 0.81 | PPARG (0.55) | PPARGPPARDPPARAL3MBTL1CYP2C19 | |
| SCHEMBL10865232 | 0.81 | PPARG (0.51) | PPARGPPARDPPARAL3MBTL1CYP2C19 | |
| SCHEMBL364427 | 0.81 | ALDH1A1 (0.42) | L3MBTL1CYP2C19CYP2C9KMT2ANPSR1 | |
| SCHEMBL383209 | 0.81 | TAS1R3 (0.42) | L3MBTL1CYP2C19CYP2C9KMT2ANPSR1 | |
| SCHEMBL10608754 | 0.80 | ACHE (0.54) | PPARGPPARDPPARAL3MBTL1CYP2C19 | |
| SCHEMBL10415398 | 0.79 | PPARG (0.50) | PPARGPPARDPPARAL3MBTL1CYP2C19 | |
| SCHEMBL84033 | 0.79 | PPARG (0.53) | PPARGPPARDPPARAL3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106957320-B | The preparation method of biologically active benzo tetrahydropyrrole compounds | 上海博栋化学科技有限公司 | 2018-10-23 | — | — | CN | claimed |
| CN-104650005-B | A kind of synthetic method of Pinaverium Bromide | 北京万生药业有限责任公司 | 2018-10-12 | — | — | CN | claimed |
| CN-106977523-A | FSHR antagonists with phenyl and nafoxidine structure and preparation method thereof | 河南师范大学 | 2017-07-25 | — | — | CN | claimed |
| CN-106957320-A | The preparation method of benzo tetrahydropyrrole compounds with bioactivity | 毛阿龙 | 2017-07-18 | — | — | CN | claimed |
| CN-106957320-B | The preparation method of biologically active benzo tetrahydropyrrole compounds | 上海博栋化学科技有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-104650005-B | A kind of synthetic method of Pinaverium Bromide | 北京万生药业有限责任公司 | 2018-10-12 | — | — | CN | disclosed |
| CN-106977523-A | FSHR antagonists with phenyl and nafoxidine structure and preparation method thereof | 河南师范大学 | 2017-07-25 | — | — | CN | disclosed |
| CN-106957320-A | The preparation method of benzo tetrahydropyrrole compounds with bioactivity | 毛阿龙 | 2017-07-18 | — | — | CN | disclosed |
| CN-102503752-B | Method for preparing polysubstituted 2-naphthol | UNIV DALIAN TECH | 2014-04-02 | — | — | CN | disclosed |
| US-8188139-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2012-05-29 | — | — | US | disclosed |
| EP-1848694-B1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | HOFFMANN LA ROCHE (CH) | 2009-11-25 | — | — | EP | disclosed |
| US-20090203665-A1 | HETEROCYCLIC-SUBSTITUTED PHENYL METHANONES | JOLIDON SYNESE | 2009-08-13 | — | — | US | disclosed |
| US-7557114-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20060178381-A1 | Heterocyclic-substituted phenyl methanones | HOFFMANN-LA ROCHE INC. | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203665-A1 | HETEROCYCLIC-SUBSTITUTED PHENYL METHANONES | CYP2B6, CYP2D6, CYP1A2 | PPARG 157/4885PPARD 407/4885PPARA 259/4885 |
| US-20060178381-A1 | Heterocyclic-substituted phenyl methanones | CYP2B6, CYP2D6, CYP1A2 | PPARG 157/4885PPARD 407/4885PPARA 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.