Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 6/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10866334 | 0.91 | HRH4 (0.55) | HRH4MMP9MMP8MMP2CAPN1 | |
| SCHEMBL10866332 | 0.91 | HRH4 (0.55) | HRH4MMP9MMP8MMP2CAPN1 | |
| SCHEMBL10772765 | 0.90 | HRH4 (0.44) | HRH4MMP9MMP8MMP2CAPN1 | |
| SCHEMBL10722646 | 0.84 | CASP3 (0.48) | HRH4RENCTSSCTSKCTSB | |
| SCHEMBL7289339 | 0.83 | PSMB5 (0.47) | MMP9MMP8MMP2CAPN1REN | |
| SCHEMBL7289346 | 0.83 | PSMB5 (0.47) | MMP9MMP8MMP2CAPN1REN | |
| SCHEMBL7286089 | 0.77 | REN (0.53) | HRH4MMP9MMP8MMP2CAPN1 | |
| SCHEMBL7286077 | 0.77 | REN (0.53) | HRH4MMP9MMP8MMP2CAPN1 | |
| SCHEMBL7291431 | 0.76 | CTSS (0.61) | HRH4MMP9MMP8MMEACE | |
| SCHEMBL7291419 | 0.76 | CTSS (0.61) | HRH4MMP9MMP8MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186977-A2 | Renin-inhibitory dipeptides, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-07-09 | — | — | EP | disclosed |