Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 5/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.40 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.39 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289346 | 1.00 | PSMB5 (0.47) | PSMB5PSMB8RENPSMB9PSMB10 | |
| SCHEMBL10869262 | 0.83 | HRH4 (0.45) | RENMMP9MMP8MMP14MMP2 | |
| SCHEMBL10722646 | 0.79 | CASP3 (0.48) | REN | |
| SCHEMBL10772765 | 0.75 | HRH4 (0.44) | RENMMP9MMP8MMP2CAPN1 | |
| SCHEMBL10866334 | 0.74 | HRH4 (0.55) | RENMMP9MMP8MMP14MMP2 | |
| SCHEMBL10866332 | 0.74 | HRH4 (0.55) | RENMMP9MMP8MMP14MMP2 | |
| SCHEMBL29557925 | 0.73 | REN (0.54) | REN | |
| SCHEMBL9716841 | 0.73 | REN (0.54) | REN | |
| SCHEMBL7291431 | 0.72 | CTSS (0.61) | PSMB5PSMB8PSMB9PSMB10PSMB2 | |
| SCHEMBL7291419 | 0.72 | CTSS (0.61) | PSMB5PSMB8PSMB9PSMB10PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |