Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10562751 | 0.98 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL351486 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL29860539 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL3701892 | 0.83 | TDP1 (0.56) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL6992814 | 0.83 | TDP1 (0.56) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL3712426 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| Bicarbonate SCHEMBL10870596 | 0.82 | TDP1 (0.75) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL28384025 | 0.82 | ALDH1A1 (0.95) | ALDH1A1MAPTSMN1; SMN2HPGDALOX15 | |
| SCHEMBL3574871 | 0.82 | TDP1 (0.54) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD | |
| SCHEMBL20537681 | 0.81 | PIM1 (0.53) | ALDH1A1MAPTSMN1; SMN2TDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119585247-A | Bicyclic heterocyclic amide inhibitors of nav1.8 for the treatment of pain | 赛特温治疗公司 | 2025-03-07 | — | — | CN | disclosed |
| EP-4514789-A1 | <SUP2/>? <SUB2/>?V?BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA1.8 FOR THE TREATMENT OF PAIN | SiteOne Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| US-11976083-B2 | Inhibitors of peptidylarginine deiminases | GILEAD SCIENCES, INC. (US) | 2024-05-07 | — | — | US | disclosed |
| CN-115551862-B | Macrocyclic inhibitors of peptidyl arginine deiminase | 吉利德科学公司 | 2024-04-12 | — | — | CN | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |
| EP-4143189-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |
| US-20230002412-A1 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. | 2023-01-05 | — | — | US | disclosed |
| US-20230002412-A1 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. | 2023-01-05 | — | — | US | disclosed |
| CN-115551862-A | Macrocyclic inhibitors of peptidyl arginine deiminase | 吉利德科学公司 | 2022-12-30 | — | — | CN | disclosed |
| WO-2011105628-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-09-01 | — | — | WO | disclosed |
| US-7741325-B2 | Benzo[b]chromeno-naphthyridin-7-one and pyrano[2′,3′:7,8]quino[2,3-b]quinoxalin-7-one compounds | LES LABORATOIRES SERVIER (FR) | 2010-06-22 | — | — | US | disclosed |
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | BAGULEY BRUCE CHARLES | 2009-06-18 | — | — | US | disclosed |
| US-7504507-B2 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-03-17 | — | — | US | disclosed |
| EP-1507778-A4 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | UNIV TROBE (AU) | 2006-05-31 | — | — | EP | disclosed |
| US-20050245561-A1 | Anti-tumour polycyclic carboxamides | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-11-03 | — | — | US | disclosed |
| US-20050171114-A1 | Benzo[b]chromeno-naphthyridin-7-one and pyrano[2',3':7,8]quino[2,3-b]quinoxalin-7-one compounds | LES LABORATOIRES SERVIER (FR) | 2005-08-04 | — | — | US | disclosed |
| EP-1507778-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | LA TROBE UNIVERSITY (AU) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097642-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | LA TROBE UNIVERSITY (AU) | 2003-11-27 | — | — | WO | disclosed |
| US-4349674-A | Quinoalinyl esters of carbamimidothioic acids | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | MKI67, MCL1, CCNI | ALDH1A1 657/4885MAPT 4168/4885SMN1; SMN2 2755/4885 |
| US-20050245561-A1 | Anti-tumour polycyclic carboxamides | MKI67, MCL1, CCNI | ALDH1A1 649/4885MAPT 3981/4885SMN1; SMN2 2519/4885 |
| US-11976083-B2 | Inhibitors of peptidylarginine deiminases | PADI4, PADI2, PADI1 | ALDH1A1 2537/4885MAPT 3578/4885SMN1; SMN2 2054/4885 |
| US-20050171114-A1 | Benzo[b]chromeno-naphthyridin-7-one and pyrano[2',3':7,8]quino[2,3-b]quinoxalin-7-one compounds | CBR1, RB1, CBR3 | ALDH1A1 955/4885MAPT 4292/4885SMN1; SMN2 3641/4885 |
| US-20230002412-A1 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | PADI4, PADI2, PADI1 | ALDH1A1 2537/4885MAPT 3578/4885SMN1; SMN2 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.