Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.43 |
| ▸ | CSNK1G3 | Q9Y6M4 | 4/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.43 |
| ▸ | MATK | P42679 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12781591 | 0.81 | GRIA1 (0.62) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D | |
| SCHEMBL3522362 | 0.77 | GRIA1 (0.58) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D | |
| SCHEMBL5935853 | 0.77 | PDE2A (0.34) | GRIA1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL16747917 | 0.75 | CYP11B1 (0.37) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D | |
| SCHEMBL13377066 | 0.71 | KDM5B (0.41) | GRIA1MAPK1GAAKDM4EALDH1A1 | |
| SCHEMBL3521737 | 0.71 | TUBB4A (0.53) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D | |
| SCHEMBL2068605 | 0.71 | TUBB4A (0.53) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D | |
| SCHEMBL7218478 | 0.70 | PTGS2 (0.60) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D | |
| SCHEMBL7221055 | 0.70 | GRIA1 (0.54) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D | |
| SCHEMBL3522644 | 0.68 | PRKD3 (0.62) | GRIA1PRKD3MAPK9CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424867-B1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LTD (GB) | 2013-09-18 | — | — | EP | disclosed |
| EP-2424867-B1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LTD (GB) | 2013-09-18 | — | — | EP | disclosed |
| US-8513248-B2 | 5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine derivatives as P2X7 modulators | GLAXO GROUP LIMITED (GB) | 2013-08-20 | — | — | US | disclosed |
| US-8513248-B2 | 5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine derivatives as P2X7 modulators | GLAXO GROUP LIMITED (GB) | 2013-08-20 | — | — | US | disclosed |
| US-8513248-B2 | 5,6,7,8-tetrahydroimidazo[1,2-A]pyrazine derivatives as P2X7 modulators | GLAXO GROUP LIMITED (GB) | 2013-08-20 | — | — | US | disclosed |
| US-20120172366-A1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2012-07-05 | — | — | US | disclosed |
| US-20120172366-A1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2012-07-05 | — | — | US | disclosed |
| US-20120172366-A1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2012-07-05 | — | — | US | disclosed |
| EP-2424867-A1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125101-A1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010125101-A1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172366-A1 | 5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | P2RX7, P2RX6, P2RX3 | GRIA1 413/4885PRKD3 1794/4885MAPK9 1447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.