Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | C1R | P00736 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10882048 | 0.84 | L3MBTL1 (0.39) | ADRA2CADRA1DADRA1AADRA1BCYP3A4 | |
| SCHEMBL10886134 | 0.82 | FABP4 (0.36) | FABP4FABP3ADRA2AADRA2CADRA1D | |
| SCHEMBL10886957 | 0.78 | KDM4E (0.48) | HSD17B10GAA | |
| SCHEMBL10791105 | 0.76 | LMNA (0.46) | PARP1 | |
| SCHEMBL10884619 | 0.74 | MAPT (0.47) | FABP4ADRA2CCYP3A4CYP2C19HSD17B10 | |
| SCHEMBL10887323 | 0.73 | ADRA2C (0.51) | ADRA2CGAAADRA2BPIK3CAPIK3CB | |
| SCHEMBL16016408 | 0.73 | MPO (0.42) | ADORA2AADORA1 | |
| SCHEMBL10884796 | 0.71 | ADRA2A (0.37) | FABP4FABP3ADRA2AADRA2CADRA1D | |
| SCHEMBL10792280 | 0.71 | SMN1; SMN2 (0.49) | ADORA2AADORA1 | |
| SCHEMBL10883114 | 0.69 | MAP3K8 (0.43) | ADRA2AADRA2CADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081324-B1 | SUBSTITUTED PHARMACOLOGICALLY ACITVE IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1986-08-06 | — | — | EP | disclosed |
| US-4517198-A | Diuretic imidazole derivatives | FARMOS GROUP LTD. (FI) | 1985-05-14 | — | — | US | disclosed |
| EP-0081324-A2 | Substituted pharmacologically acitve imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-06-15 | — | — | EP | disclosed |