Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL10945748 | 1.00 | PGR (0.70) | PGRTDP1NR3C1LMNAPDE4D | |
| Potassium Ion SCHEMBL10883783 | 1.00 | PGR (0.70) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL6707070 | 0.91 | PGR (0.57) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL6707066 | 0.91 | PGR (0.57) | PGRTDP1NR3C1LMNAPDE4D | |
| SCHEMBL7793508 | 0.84 | PGR (0.50) | PGRTDP1NR3C1LMNAPDE4D | |
| Potassium Ion SCHEMBL10886695 | 0.83 | TDP1 (0.52) | PGRTDP1NR3C1LMNAPDE4D | |
| Potassium Ion SCHEMBL10943952 | 0.83 | TDP1 (0.52) | PGRTDP1NR3C1LMNAPDE4D | |
| Potassium Ion SCHEMBL10886690 | 0.83 | TDP1 (0.52) | PGRTDP1NR3C1LMNAPDE4D | |
| Canrenoate SCHEMBL124160 | 0.83 | PGR (1.00) | PGRTDP1NR3C1LMNAPDE4D | |
| Canrenoate SCHEMBL49729 | 0.83 | PGR (1.00) | PGRTDP1NR3C1LMNAPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115273-B1 | ALDOSTERONE-ANTAGONISTIC STEROIDS | SHIONOGI & CO., LTD. (JP) | 1986-11-20 | — | — | EP | claimed |
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | claimed |
| EP-0115273-A2 | Aldosterone-antagonistic steroids | SHIONOGI & CO., LTD. (JP) | 1984-08-08 | — | — | EP | claimed |
| EP-0115273-B1 | ALDOSTERONE-ANTAGONISTIC STEROIDS | SHIONOGI & CO., LTD. (JP) | 1986-11-20 | — | — | EP | disclosed |
| US-4502989-A | HYPOTENSIVE, ANTIEDEMIC | SHIONOGI & CO., LTD. (JP) | 1985-03-05 | — | — | US | disclosed |
| EP-0115273-A2 | Aldosterone-antagonistic steroids | SHIONOGI & CO., LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |