Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15242463 | 0.87 | ALDH1A1 (0.32) | LMNA | |
| SCHEMBL8072275 | 0.86 | ROCK2 (0.43) | ROCK2ROCK1ALOX5LMNATDP1 | |
| SCHEMBL1227336 | 0.86 | ROCK2 (0.43) | ROCK2ROCK1ALOX5LMNATDP1 | |
| SCHEMBL11080452 | 0.86 | ROCK2 (0.43) | ROCK2ROCK1ALOX5LMNATDP1 | |
| SCHEMBL12868770 | 0.83 | TSHR (0.32) | ROCK2ROCK1 | |
| SCHEMBL26492652 | 0.83 | TSHR (0.32) | ROCK2ROCK1 | |
| SCHEMBL15080322 | 0.83 | TSHR (0.32) | ROCK2ROCK1 | |
| SCHEMBL824158 | 0.82 | ACE (0.39) | ROCK2ROCK1ALOX5LMNATDP1 | |
| SCHEMBL14436548 | 0.82 | ACE (0.39) | ROCK2ROCK1ALOX5LMNATDP1 | |
| SCHEMBL25544782 | 0.82 | ACE (0.39) | ROCK2ROCK1ALOX5LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11723990-B2 | Library of pH responsive polymers and nanoprobes thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-08-15 | — | — | US | disclosed |
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-05-10 | — | — | US | disclosed |
| US-20170210699-A1 | PREPARATION AND BIOLOGICAL EVALUATION OF VIRIDICATUMTOXIN ANALOGS | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-07-27 | — | — | US | disclosed |
| US-20130252883-A1 | Macrocycles and Their Uses | NOVARTIS AG (CH) | 2013-09-26 | — | — | US | disclosed |
| US-8476224-B2 | Macrocycles and their uses | NOVARTIS AG (US) | 2013-07-02 | — | — | US | disclosed |
| US-8425784-B2 | Ozonolysis reactions in liquid CO2 and CO2-expanded solvents | UNIVERSITY OF KANSAS (US) | 2013-04-23 | — | — | US | disclosed |
| US-20090118498-A1 | OZONOLYSIS REACTIONS IN LIQUID CO2 AND CO2-EXPANDED SOLVENTS | ARCHER DANIELS MIDLAND COMPANY | 2009-05-07 | — | — | US | disclosed |
| US-20070276138-A1 | Modulators of peroxisome proliferator activated receptors | BROOKS DAWN A | 2007-11-29 | — | — | US | disclosed |
| US-7192982-B2 | Modulators of peroxisome proliferator activated receptors | LIGAND PHARMACEUTICALS, INC. (US) | 2007-03-20 | — | — | US | disclosed |
| EP-0103486-B1 | SMOKING COMPOSITIONS | PHILIP MORRIS INCORPORATED (US) | 1986-11-20 | — | — | EP | disclosed |
| US-4547568-A | RELEASING FLAVOR UPON SMOKING | PHILIP MORRIS INCORPORATED (US) | 1985-10-15 | — | — | US | disclosed |
| US-4481956-A | B-KETOCARBOXYLIC ACID ESTER OF CARBOHYDRATE OF ALGOLHOL | PHILIP MORRIS INCORPORATED (US) | 1984-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | REN, MAN2B2, UTS2R | ROCK2 2980/4885ROCK1 2414/4885ALOX5 4014/4885 |
| US-20130252883-A1 | Macrocycles and Their Uses | MRPL21, CLPP, MLEC | ROCK2 2204/4885ROCK1 2782/4885ALOX5 2556/4885 |
| US-20170210699-A1 | PREPARATION AND BIOLOGICAL EVALUATION OF VIRIDICATUMTOXIN ANALOGS | VIP, DDOST, ANTXR2 | ROCK2 2179/4885ROCK1 1481/4885ALOX5 509/4885 |
| US-11723990-B2 | Library of pH responsive polymers and nanoprobes thereof | MSN, CD44, CD47 | ROCK2 515/4885ROCK1 561/4885ALOX5 3751/4885 |
| US-20070276138-A1 | Modulators of peroxisome proliferator activated receptors | PPARG, NCOA4, PPARA | ROCK2 4526/4885ROCK1 4781/4885ALOX5 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.