Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.33 |
| ▸ | TP53 | P04637 | 6/20 | 0.33 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10891246 | 0.83 | GAA (0.40) | TSHRSMN1; SMN2HTTMAPTRAB9A | |
| SCHEMBL10890235 | 0.78 | TSHR (0.39) | TSHRSMN1; SMN2HPGDHTTMAPT | |
| SCHEMBL10894284 | 0.75 | DRD3 (0.33) | TSHRSMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL13387645 | 0.72 | PDK1 (0.36) | TSHRMAPTRAB9ATP53NPC1 | |
| Evandamine SCHEMBL6009808 | 0.72 | APOBEC3A (0.42) | TSHRSMN1; SMN2HTTMAPTRAB9A | |
| SCHEMBL6999293 | 0.70 | TSHR (0.61) | TSHRSMN1; SMN2HPGDHTTMAPT | |
| SCHEMBL10891764 | 0.69 | MEN1 (0.45) | TSHRSMN1; SMN2MAPTRAB9ATP53 | |
| SCHEMBL11061030 | 0.69 | ABL1 (0.50) | GAALMNAABL1MEN1KMT2A | |
| SCHEMBL11061324 | 0.68 | ABL1 (0.55) | MAPTRAB9ANPC1GAALMNA | |
| SCHEMBL11060498 | 0.67 | ABL1 (0.48) | GAAABL1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600722-A | 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazolines and a process for the treatment of inflammatory or allergic processes in humans | A. NATTERMANN & CIE GMBH (DE) | 1986-07-15 | — | — | US | disclosed |
| EP-0155523-A1 | 3-Amino-1-(4,5,6,7-Tetrahydro-benzothiazolyl)-2-Pyrazolines,a process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-25 | — | — | EP | disclosed |