Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.36 |
| ▸ | FBP1 | P09467 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Evandamine SCHEMBL6009808 | 0.83 | APOBEC3A (0.42) | PDK1FBP1APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL10894284 | 0.76 | DRD3 (0.33) | PDK1FBP1APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL10891246 | 0.73 | GAA (0.40) | TSHRMEN1ALDH1A1LMNAGAA | |
| SCHEMBL10891333 | 0.72 | TSHR (0.38) | TSHRMEN1ALDH1A1LMNAGAA | |
| SCHEMBL1891504 | 0.66 | APOBEC3A (0.42) | PDK1FBP1APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL16695138 | 0.64 | SMN1; SMN2 (0.53) | PDK1FBP1APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL10891545 | 0.64 | ALDH1A1 (0.36) | TSHRMEN1ALDH1A1LMNAGAA | |
| SCHEMBL10890556 | 0.63 | MAPT (0.40) | APOBEC3AAPOBEC3GTSHRJAK2MAP4K4 | |
| SCHEMBL12210600 | 0.63 | PDK1 (0.54) | PDK1FBP1APOBEC3AAPOBEC3GTSHR | |
| SCHEMBL10893459 | 0.62 | APOBEC3A (0.49) | PDK1FBP1APOBEC3AAPOBEC3GTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705160-B2 | Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-04-27 | — | — | US | disclosed |
| US-7705160-B2 | Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-04-27 | — | — | US | disclosed |
| US-20080108821-A1 | Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles | FMC CORPORATION | 2008-05-08 | — | — | US | disclosed |
| US-20080108821-A1 | Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles | FMC CORPORATION | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108821-A1 | Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles | HAX1, CXCR1, H1-4 | PDK1 968/4885FBP1 2677/4885APOBEC3A 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.