Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 7/20 | 0.50 |
| ▸ | PPARD | Q03181 | 7/20 | 0.50 |
| ▸ | PPARA | Q07869 | 7/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL106852 | 0.92 | CA1 (0.58) | FABP3CA1SLC22A1 | |
| Tetrabuthylammonium SCHEMBL109358 | 0.90 | AKR1B1 (0.56) | AKR1B1GPR84PPARGPPARDPPARA | |
| Tetrabuthylammonium SCHEMBL104377 | 0.90 | AKR1B1 (0.61) | AKR1B1GPR84PPARGPPARDPPARA | |
| Tetrabuthylammonium SCHEMBL108933 | 0.89 | AKR1B1 (0.64) | AKR1B1GPR84PPARGPPARDPPARA | |
| Tetrabuthylammonium SCHEMBL2230707 | 0.89 | GPR84 (0.63) | AKR1B1GPR84PPARGPPARDPPARA | |
| Tetrapropylammonium SCHEMBL108660 | 0.88 | FFAR3 (0.48) | AKR1B1GPR84PPARGPPARDPPARA | |
| Tetrabuthylammonium SCHEMBL28405433 | 0.87 | AKR1B1 (0.61) | AKR1B1GPR84PPARGPPARDPPARA | |
| Tetrabuthylammonium SCHEMBL106828 | 0.85 | CA1 (0.62) | FABP3CA1SLC22A1 | |
| Tetrabuthylammonium SCHEMBL106827 | 0.85 | CA1 (0.70) | FABP3CA1SLC22A1 | |
| Tetrabuthylammonium SCHEMBL107057 | 0.85 | FFAR3 (0.64) | GPR84FABP3CA1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515998-B | Synthesis of polyurethanes by chain growth copolymerization | 伊夫·雅努 | 2025-06-24 | — | — | CN | claimed |
| WO-2025118889-A1 | SI-O-SI FRAMEWORK BRIDGED MULTI-NUCLEAR BORON CATALYST, PREPARATION METHOD THEREFOR AND USE THEREOF | 青岛科技大学 | 2025-06-12 | — | — | WO | claimed |
| CN-119350626-A | Si-O-Si based bone bridging polynuclear boron catalyst and preparation method and application thereof | 青岛科技大学 | 2025-01-24 | — | — | CN | claimed |
| CN-119192210-A | Preparation method and application of chiral spiro diborane organic catalyst | 青岛科技大学 | 2024-12-27 | — | — | CN | claimed |
| CN-118206730-A | Tetrachlorophthalic anhydride/ethylene oxide/propylene oxide/carbon dioxide tetrapolymer and preparation method thereof | 中山大学 | 2024-06-18 | — | — | CN | claimed |
| WO-2023194883-A1 | COPOLYMERIZATION OF ORTHO-PHTHALDEHYDE WITH MONOMERS | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2023-10-12 | — | — | WO | claimed |
| WO-2023152730-A1 | AMINE-BORANE ADDUCTS IN THE SYNTHESIS OF POLYESTER AND ITS COPOLYMERS USING CYCLIC ESTERS AND COMPOSITIONS THEREOF | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2023-08-17 | — | — | WO | claimed |
| US-20230242699-A1 | POLYCARBAMATE SYNTHESIS VIA CHAIN-GROWTH COPOLYMERIZATION | FENG, Xiaoshuang (CN) | 2023-08-03 | — | — | US | claimed |
| EP-4146716-A1 | POLYCARBAMATE SYNTHESIS VIA CHAIN-GROWTH COPOLYMERIZATION | King Abdullah University Of Science And Technology (SA) | 2023-03-15 | — | — | EP | claimed |
| CN-115109241-A | Ethylene oxide based copolymers | 阿卜杜拉国王科技大学 | 2022-09-27 | — | — | CN | claimed |
| US-20220194941-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR MAKING (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-l,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | US | claimed |
| CN-114206851-A | Process for the preparation of intermediates useful in the preparation of (2S,5R) -7-oxo-N-piperidin-4-yl-6- (sulfate) -1, 6-diazabicyclo [3.2.1] octane-2-carboxamide | 默沙东公司 | 2022-03-18 | — | — | CN | claimed |
| EP-3959205-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR MAKING (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE | Merck Sharp & Dohme Corp. (US) | 2022-03-02 | — | — | EP | claimed |
| WO-2021224866-A1 | POLYCARBAMATE SYNTHESIS VIA CHAIN-GROWTH COPOLYMERIZATION | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2021-11-11 | — | — | WO | claimed |
| US-20210309801-A1 | ETHYLENE OXIDE-BASED COPOLYMERS | KING ABDULLAH UNIVERSITY OF SCIENCE & TECHNOLOGY (SA) | 2021-10-07 | — | — | US | claimed |
| WO-2020219405-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR MAKING (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE | MERCK SHARP & DOHME CORP. (US) | 2020-10-29 | — | — | WO | claimed |
| US-10246558-B2 | Compositions comprising siloxane compounds and methods for using the same | MILLIKEN & COMPANY (US) | 2019-04-02 | — | — | US | claimed |
| EP-3458498-A1 | COMPOSITIONS COMPRISING SILOXANE COMPOUNDS AND METHODS FOR USING THE SAME | Milliken & Company (US) | 2019-03-27 | — | — | EP | claimed |
| US-20170335065-A1 | COMPOSITIONS COMPRISING SILOXANE COMPOUNDS AND METHODS FOR USING THE SAME | MILLIKEN & COMPANY | 2017-11-23 | — | — | US | claimed |
| WO-2017201035-A1 | COMPOSITIONS COMPRISING SILOXANE COMPOUNDS AND METHODS FOR USING THE SAME | MILLIKEN & COMPANY (US) | 2017-11-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194941-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR MAKING (2S,5R)-7-OXO-N-PIPERIDIN-4-YL-6-(SULFOXY)-l,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDE | OGA, SULT1E1, UCHL5 | AKR1B1 1658/4885GPR84 4215/4885PPARG 3683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.