Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679028 | 0.88 | PTGS2 (0.44) | SRD5A2AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL7674820 | 0.87 | SRD5A2 (0.44) | SRD5A2PTGS2PTGS1KDM4EMEN1 | |
| SCHEMBL7676788 | 0.86 | PTGS2 (0.51) | SRD5A2AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL7678368 | 0.83 | MAPT (0.51) | SRD5A2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL8336761 | 0.74 | GRM5 (0.39) | GRM5SRD5A2AKR1C3AKR1C2PTGS2 | |
| SCHEMBL11809649 | 0.73 | SIRT1 (0.49) | PTGS2ABCB11TSHRHTTKMT2A | |
| SCHEMBL11808855 | 0.73 | ALDH1A1 (0.41) | SRD5A2AKR1C3MEN1KMT2A | |
| SCHEMBL8519374 | 0.73 | PTGS2 (0.34) | GRM5PTGS2PTGS1TSHRKDM4E | |
| SCHEMBL7674517 | 0.73 | LTA4H (0.43) | SRD5A2LTA4HCES2CES1 | |
| SCHEMBL10781824 | 0.71 | KMT2A (0.44) | AKR1C3PTGS2PTGS1AGBL2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067370-B1 | PROCESS FOR THE PREPARATION OF ZOMEPIRAC AND RELATED COMPOUNDS | MERCK & CO. INC. (US) | 1986-03-19 | — | — | EP | disclosed |
| US-4374997-A | Process for the preparation of zomepirac and related compounds | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0067370-A2 | Process for the preparation of zomepirac and related compounds | MERCK & CO. INC. (US) | 1982-12-22 | — | — | EP | disclosed |