Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10916739 | 0.99 | HSD11B1 (0.49) | HSD11B1BCHEACHEOPRM1NR3C1 | |
| SCHEMBL10918399 | 0.90 | CCR2 (0.45) | HSD11B1BCHEACHENR3C1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10915699 | 0.88 | SIGMAR1 (0.49) | ALDH1A1LMNASIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL10916011 | 0.87 | ACHE (0.48) | BCHEACHEALDH1A1LMNASIGMAR1 | |
| SCHEMBL10914304 | 0.87 | ACHE (0.44) | BCHEACHEOPRM1ALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10973696 | 0.85 | NPC1 (0.47) | HSD11B1OPRM1NR3C1CHRM4RAB9A | |
| Hydrochloric Acid SCHEMBL10916193 | 0.84 | DRD2 (0.47) | OPRM1ALDH1A1LMNASIGMAR1KDM4E | |
| SCHEMBL10917978 | 0.84 | ALDH1A1 (0.49) | ALDH1A1LMNAHPGDHIF1ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10917762 | 0.84 | PDE3B (0.51) | ALDH1A1LMNASIGMAR1KDM4E | |
| SCHEMBL10916248 | 0.83 | ALDH1A1 (0.51) | ALDH1A1LMNAHPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064707-B1 | 4-(4-PHENYL-1-PIPERIDINYL)METHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-07-23 | — | — | EP | claimed |
| EP-0064707-A1 | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | claimed |
| US-4329471-A | CARDIOTONICS, HYPOTENSIVE AGENTS, AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | claimed |