SCHEMBL10922018

SCHEMBL10922018

CCCNC(=O)Nc1ccccc1C(=O)O

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.69
CFD P00746 1/20 0.65
EPHX1 P07099 1/20 0.61
CYP2C9 P11712 1/20 0.61
HPGD P15428 1/20 0.61
GAA P10253 3/20 0.55
POLB P06746 2/20 0.55
KMT2A Q03164 1/20 0.54
KDM4E B2RXH2 2/20 0.54
ABCC1 P33527 1/20 0.54
CA12 O43570 2/20 0.51
CA2 P00918 2/20 0.51
CA9 Q16790 2/20 0.51
ALDH1A1 P00352 2/20 0.51
ITGB3 P05106 1/20 0.51
ITGAV P06756 1/20 0.51
MASP2 O00187 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8556765 0.89 L3MBTL1 (0.68) L3MBTL1CFDEPHX1CYP2C9HPGD
SCHEMBL13614088 0.87 GAA (0.71) L3MBTL1CFDCYP2C9HPGDGAA
SCHEMBL10362611 0.84 GAA (0.78) L3MBTL1EPHX1HPGDGAAKMT2A
SCHEMBL8458301 0.84 CFD (0.65) L3MBTL1CFDCYP2C9HPGDGAA
SCHEMBL27358385 0.83 CFD (0.72) L3MBTL1CFDEPHX1GAAKMT2A
SCHEMBL7751829 0.82 KDM4E (0.64) L3MBTL1EPHX1HPGDGAAKDM4E
SCHEMBL4749159 0.80 DHODH (0.69) CFDKMT2AKDM4ECA12CA2
SCHEMBL7443824 0.80 ITGB3 (0.71) L3MBTL1EPHX1HPGDGAAPOLB
SCHEMBL8803821 0.80 EPHX1 (0.65) L3MBTL1EPHX1GAAPOLBALDH1A1
SCHEMBL1902821 0.80 HPGD (0.69) L3MBTL1CYP2C9HPGDPOLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2590976-A1 IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2013-05-15 EP disclosed
WO-2012004732-A1 IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-01-12 WO disclosed
EP-0076199-B1 TRIAZOLOQUINAZOLONES AND THEIR SALTS, PROCESS AND INTERMEDIATES FOR PREPARING THEM, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1986-12-30 EP disclosed
EP-0076199-A2 Triazoloquinazolones and their salts, process and intermediates for preparing them, their use as medicines and compositions containing them ROUSSEL-UCLAF (FR) 1983-04-06 EP disclosed