Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | CES2 | O00748 | 4/20 | 0.58 |
| ▸ | CES1 | P23141 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820544 | 1.00 | LMNA (0.58) | LMNACES2CES1TDP1L3MBTL1 | |
| SCHEMBL27003 | 1.00 | LMNA (0.58) | LMNACES2CES1TDP1L3MBTL1 | |
| Methane SCHEMBL9356267 | 0.98 | LMNA (0.56) | LMNACES2CES1TDP1L3MBTL1 | |
| SCHEMBL27719890 | 0.98 | LMNA (0.56) | LMNACES2CES1TDP1L3MBTL1 | |
| SCHEMBL10944827 | 0.91 | ALDH1A1 (0.58) | LMNACES2CES1TDP1L3MBTL1 | |
| Acrylic Acid SCHEMBL28676895 | 0.88 | AKT1 (0.50) | LMNACES2CES1TDP1L3MBTL1 | |
| SCHEMBL21456599 | 0.87 | KDM4E (0.43) | LMNACES2CES1PGRADRA2A | |
| SCHEMBL29234971 | 0.84 | LMNA (0.44) | LMNACES2CES1TDP1L3MBTL1 | |
| Phenylglycine SCHEMBL28088318 | 0.83 | LMNA (0.52) | LMNACES2CES1TDP1L3MBTL1 | |
| Piperidine SCHEMBL6693285 | 0.83 | LMNA (0.43) | LMNACES2CES1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316926-B1 | Enantioselective production of alpha-hydroxy carbonyl compounds | UNIV BONN (DE) | 2016-04-13 | — | — | EP | claimed |
| EP-2316926-A1 | Enantioselective production of alpha-hydroxy carbonyl compounds | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2011-05-04 | — | — | EP | claimed |
| US-9527823-B2 | Hydroxybupropion analogues for treating drug dependence | RESEARCH TRIANGLE INSTITUTE (US) | 2016-12-27 | — | — | US | disclosed |
| EP-2316926-B1 | Enantioselective production of alpha-hydroxy carbonyl compounds | UNIV BONN (DE) | 2016-04-13 | — | — | EP | disclosed |
| EP-2571859-B1 | 1-PHENYLMORPHOLINE DERIVATIVES AS HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE | RES TRIANGLE INST (US) | 2015-07-22 | — | — | EP | disclosed |
| US-20150141416-A1 | HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE | RESEARCH TRIANGLE INSTITUTE | 2015-05-21 | — | — | US | disclosed |
| US-8906908-B2 | Hydroxybupropion analogues for treating drug dependence | RESEARCH TRIANGLE INSTITUTE (US) | 2014-12-09 | — | — | US | disclosed |
| US-20130150357-A1 | HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE | RESEARCH TRIANGLE INSTITUTE (US) | 2013-06-13 | — | — | US | disclosed |
| US-8153408-B2 | Biocatalytic racemisation of alpha-hydroxyketones | BASF SE (DE) | 2012-04-10 | — | — | US | disclosed |
| EP-2316926-A1 | Enantioselective production of alpha-hydroxy carbonyl compounds | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2011-05-04 | — | — | EP | disclosed |
| EP-1984515-B1 | BIOCATALYTIC RACEMISATION OF ALPHA-HYDROXYKETONES | BASF SE (DE) | 2010-09-01 | — | — | EP | disclosed |
| US-20090221046-A1 | BIOCATALYTIC RACEMISATION OF ALPHA-HYDROXYKETONES | BASF SE (DE) | 2009-09-03 | — | — | US | disclosed |
| US-7045334-B2 | Nucleotide sequence encoding a benzaldehyde lyase, and process for stereoselectively synthesizing 2-hydroxyketones | Forschungszentrum Jülich GmbH (DE) | 2006-05-16 | — | — | US | disclosed |
| US-20040014182-A1 | Nucleotide sequence encoding a benzaldehyde lyase, and process for stereoselectively synthesizing 2-hydroxyketones | FORSCHUNGSZENTRUM JULICH GMBH (DE) | 2004-01-22 | — | — | US | disclosed |
| EP-1297159-A2 | NUCLEOTIDE SEQUENCE ENCODING BENZALDEHYDE LYASE AND METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF 2-HYDROXY KETONES | FORSCHUNGSZENTRUM JÜLICH GMBH (DE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002002753-A2 | NUCLEOTIDE SEQUENCE ENCODING BENZALDEHYDE LYASE AND METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF 2-HYDROXY KETONES | Forschungszentrum Jülich GmbH (DE) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150357-A1 | HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE | SLC6A2, SLC6A3, HTR3B | LMNA 3733/4885CES2 91/4885CES1 333/4885 |
| US-20150141416-A1 | HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE | SLC6A2, SLC6A3, HTR3B | LMNA 3733/4885CES2 91/4885CES1 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.