Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874562 | 0.88 | RAB9A (0.52) | L3MBTL1CES2CES1POLBPARP1 | |
| SCHEMBL29190944 | 0.88 | RAB9A (0.52) | L3MBTL1CES2CES1POLBPARP1 | |
| SCHEMBL10939397 | 0.83 | ALDH1A1 (0.58) | L3MBTL1POLBALDH1A1MAPTMAPK7 | |
| SCHEMBL10940195 | 0.82 | KMT2A (0.52) | L3MBTL1CES2CES1POLBPARP1 | |
| SCHEMBL10944870 | 0.82 | POLB (0.51) | L3MBTL1POLBALDH1A1KMT2AGAA | |
| SCHEMBL10942146 | 0.81 | POLB (0.54) | POLBPARP1HDAC6ALDH1A1MAPT | |
| SCHEMBL10941754 | 0.81 | ALOX15 (0.51) | L3MBTL1PARP1ALDH1A1MAPTMAPK7 | |
| SCHEMBL13950378 | 0.77 | CES2 (0.71) | L3MBTL1CES2CES1PARP1HDAC1 | |
| SCHEMBL29665004 | 0.77 | CES2 (0.71) | L3MBTL1CES2CES1PARP1HDAC1 | |
| SCHEMBL28396 | 0.77 | CES2 (0.71) | L3MBTL1CES2CES1PARP1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |