Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP9 | P55211 | 1/20 | 0.33 |
| ▸ | BAX | Q07812 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 10/20 | 0.33 |
| ▸ | HTR2B | P41595 | 8/20 | 0.33 |
| ▸ | HTR2A | P28223 | 6/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566403 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL9678335 | 0.81 | KDM4E (0.66) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL30615686 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL1915366 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| Bicarbonate SCHEMBL10873564 | 0.74 | KDM4E (0.66) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL24629101 | 0.72 | HTR2C (0.43) | LMNAHTR2CHTR2BHTR2A | |
| SCHEMBL29742967 | 0.71 | TOP2A (0.49) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10475103 | 0.71 | TOP2A (0.49) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL8882717 | 0.71 | TOP2A (0.41) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10655744 | 0.70 | KDM4E (0.47) | KDM4EALDH1A1TOP2ATOP2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0113093-B1 | 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(ALKYL-1-PIPERAZINYL)-3-QUINOLINE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1986-05-21 | — | — | EP | claimed |