Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 7/20 | 0.35 |
| ▸ | HTR2B | P41595 | 5/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882717 | 0.87 | TOP2A (0.41) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10950783 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL1915366 | 0.82 | ALDH1A1 (0.61) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL30615686 | 0.82 | ALDH1A1 (0.61) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| Bicarbonate SCHEMBL10873564 | 0.78 | KDM4E (0.66) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL20286630 | 0.77 | KCNH2 (0.48) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL8882227 | 0.76 | KDM4E (0.57) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL14585956 | 0.75 | ALDH1A1 (0.48) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL29742967 | 0.75 | TOP2A (0.49) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10475103 | 0.75 | TOP2A (0.49) | KDM4EALDH1A1TOP2ATOP2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176206-B2 | Antibiotics | DAR AL DAWA DEVELOPMENT AND INVESTMENT CO. (JO) | 2007-02-13 | — | — | US | claimed |
| US-7176206-B2 | Antibiotics | DAR AL DAWA DEVELOPMENT AND INVESTMENT CO. (JO) | 2007-02-13 | — | — | US | disclosed |
| US-20040132740-A1 | Novel antibiotics | DAR AL DAWA DEVELOPMENT AND INVESTMENT CO. (JO) | 2004-07-08 | — | — | US | disclosed |
| EP-1245566-B1 | Quinolin-4-one derivatives and their use as antibiotics | DAR AL DAWA DEV (JO) | 2004-01-07 | — | — | EP | disclosed |
| EP-1373211-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBIOTICS | Dar Al Dawa Development, and Investment Co. (JO) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079164-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBIOTICS | DAR AL DAWA DEVELOPMENT AND INVESTMENT CO. (JO) | 2002-10-10 | — | — | WO | disclosed |
| EP-1245566-A1 | Quinolin-4-one derivatives and their use as antibiotics | Dar Al Dawa Development, and Investment Co. (JO) | 2002-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132740-A1 | Novel antibiotics | DPM1, KDM5A, KDM5B | KDM4E 27/4885ALDH1A1 1584/4885TOP2A 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.