Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10949945 | 0.83 | NFKB1 (0.42) | SMN1; SMN2LMNAALDH1A1HTTNPC1 | |
| SCHEMBL93570 | 0.79 | CTSL (0.48) | SMN1; SMN2LMNAALDH1A1TDP1ALPG | |
| SCHEMBL5114349 | 0.72 | HDAC3 (0.45) | SMN1; SMN2LMNAALDH1A1ALPG | |
| SCHEMBL5114354 | 0.72 | HDAC3 (0.45) | SMN1; SMN2LMNAALDH1A1ALPG | |
| SCHEMBL6321555 | 0.72 | HDAC3 (0.45) | SMN1; SMN2LMNAALDH1A1ALPG | |
| SCHEMBL14407932 | 0.70 | ALDH1A1 (0.76) | SMN1; SMN2LMNAALDH1A1TDP1ALPG | |
| SCHEMBL2966992 | 0.70 | ALDH1A1 (0.76) | SMN1; SMN2LMNAALDH1A1TDP1ALPG | |
| SCHEMBL11947078 | 0.70 | LMNA (0.67) | SMN1; SMN2LMNAALDH1A1HTTRAB9A | |
| SCHEMBL1070238 | 0.70 | LTA4H (0.64) | SMN1; SMN2LMNAALDH1A1TDP1ALPG | |
| SCHEMBL1115120 | 0.69 | CES2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4503073-A | ANTIINFLAMMATORY, ANALGESIC, ANTICOAGULANT | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-03-05 | — | — | US | disclosed |