Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10970591 | 0.89 | ALDH1A1 (0.47) | POLBTDP1ABL1RIN1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10967357 | 0.88 | ALDH1A1 (0.47) | POLBTDP1ABL1RIN1L3MBTL1 | |
| SCHEMBL10918399 | 0.80 | CCR2 (0.45) | LMNACCR3ALDH1A1DRD2DRD4 | |
| SCHEMBL10971590 | 0.80 | POLB (0.45) | POLBLMNATDP1ABL1RIN1 | |
| SCHEMBL10930451 | 0.77 | ABL1 (0.53) | POLBTDP1ABL1RIN1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10927079 | 0.77 | ALOX15 (0.54) | POLBLMNATDP1ABL1RIN1 | |
| Hydrochloric Acid SCHEMBL10926469 | 0.76 | ALOX15 (0.56) | POLBLMNATDP1ABL1RIN1 | |
| Hydrochloric Acid SCHEMBL10925448 | 0.75 | TDP1 (0.51) | POLBTDP1ABL1RIN1L3MBTL1 | |
| SCHEMBL10967335 | 0.74 | KDM4E (0.48) | ALDH1A1DRD2DRD4DRD3MEN1 | |
| Hydrochloric Acid SCHEMBL10925060 | 0.74 | L3MBTL1 (0.68) | POLBLMNATDP1ABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064706-B1 | 5-(4-PHENYL-1-PIPERIDINYL)METHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| EP-0064706-A1 | 5-(4-Phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329470-A | CORDIOTONIC, HYPOTENSIVE, ANTITHROMBOSIS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |