Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 8/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30924933 | 0.86 | MAPT (0.63) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| Iodide SCHEMBL11813030 | 0.85 | MAPT (0.65) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| Perchlorate SCHEMBL10998853 | 0.82 | MAPT (0.58) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10971186 | 0.76 | INSR (0.59) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10971188 | 0.76 | INSR (0.59) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5477938 | 0.75 | ALDH1A1 (0.51) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL11516421 | 0.74 | INSR (0.60) | MAPTMEN1KMT2AINSRADRB2 | |
| Hydrochloric Acid SCHEMBL11516423 | 0.74 | INSR (0.60) | MAPTMEN1KMT2AINSRADRB2 | |
| Hydrochloric Acid SCHEMBL11593951 | 0.73 | ADRB2 (0.49) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| Iodide SCHEMBL8067949 | 0.71 | MAPT (0.87) | MAPTMEN1ALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0050558-B1 | PHOTOGRAPHIC EMULSIONS AND ELEMENTS CAPABLE OF FORMING DIRECT-POSITIVE IMAGES | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-07-17 | — | — | EP | disclosed |
| EP-0050558-A2 | Photographic emulsions and elements capable of forming direct-positive images | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1982-04-28 | — | — | EP | disclosed |
| US-4306016-A | HETEROCYCLIC CYANINE DYE-LIKE NUCLEATING AGENTS | EASTMAN KODAK COMPANY (US) | 1981-12-15 | — | — | US | disclosed |