Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344617 | 0.81 | PTK2B (0.46) | GABRA1GABRB2ACP3TSHRALDH1A1 | |
| SCHEMBL20526222 | 0.81 | GABRA1 (0.44) | GABRA1GABRB2ACP3TSHRALDH1A1 | |
| Zinc Ion SCHEMBL916285 | 0.79 | GABRA1 (0.38) | GABRA1GABRB2TSHRALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL10824664 | 0.79 | PTK2B (0.44) | GABRA1GABRB2ACP3TSHRALDH1A1 | |
| SCHEMBL914554 | 0.79 | GABRA1 (0.38) | GABRA1GABRB2TSHRALDH1A1POLB | |
| SCHEMBL10448564 | 0.78 | GABRA1 (0.41) | GABRA1GABRB2ACP3TSHRALDH1A1 | |
| SCHEMBL2536276 | 0.78 | GABRA1 (0.41) | GABRA1GABRB2ACP3TSHRALDH1A1 | |
| SCHEMBL6522210 | 0.78 | GABRA1 (0.41) | GABRA1GABRB2ACP3TSHRALDH1A1 | |
| Phosphoric Acid SCHEMBL28176644 | 0.75 | GABRA1 (0.52) | GABRA1GABRB2ACP3TSHRALDH1A1 | |
| SCHEMBL5002506 | 0.74 | GABRA1 (0.39) | GABRA1GABRB2ACP3TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074296-B1 | FLAME-RESISTANT RESINOUS COMPOSITION CONTAINING A POLYCARBONATE, A HEMI-ESTER OF PHOSPHONIC ACID AND OPTIONALLY OTHER ADDITIVES AND/OR FILLERS, AND HEMI-ESTERS OF PHOSPHONIC ACID | ATO CHIMIE, Société Anonyme dite: (FR) | 1985-11-06 | — | — | EP | claimed |