Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | CDH1 | P12830 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15850505 | 0.84 | KDM4E (0.45) | KDM4ELMNAGAAL3MBTL1GCGR | |
| SCHEMBL30704329 | 0.79 | ALOX5 (0.39) | KDM4ELMNAGCGRALOX5NPC1 | |
| SCHEMBL30704358 | 0.79 | ALOX15 (0.37) | KDM4EGAAGCGRNPC1RAB9A | |
| SCHEMBL17922820 | 0.79 | AHR (0.46) | KDM4EGAAL3MBTL1NPC1RAB9A | |
| SCHEMBL8935466 | 0.78 | KDM4E (0.41) | KDM4ELMNAGAAL3MBTL1GCGR | |
| SCHEMBL9451310 | 0.78 | MEN1 (0.41) | KDM4ELMNAGAAL3MBTL1ALOX5 | |
| SCHEMBL8935457 | 0.75 | NPC1 (0.45) | KDM4ELMNAGAAL3MBTL1NPC1 | |
| SCHEMBL30704313 | 0.75 | KMT2A (0.47) | KDM4ELMNANPC1RAB9AALDH1A1 | |
| SCHEMBL30704314 | 0.75 | ALDH1A1 (0.49) | KDM4ELMNAGAAL3MBTL1ALOX5 | |
| SCHEMBL8519653 | 0.73 | CA12 (0.46) | KDM4ELMNAGAAL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117327029-A | Azole derivative and preparation method thereof | 云南大学 | 2024-01-02 | — | — | CN | disclosed |
| US-9649300-B2 | Inhibition of WNT, TGF beta and Hippo signaling pathways to treat cancer, organ fibrosis and metabolic disorders | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-05-16 | — | — | US | disclosed |
| US-20160200697-A1 | INHIBITION OF WNT, TGF BETA AND HIPPO SIGNALING PATHWAYS TO TREAT CANCER, ORGAN FIBROSIS AND METABOLIC DISORDERS | University of Pittsburgh - of the Commonwealth Sys tem of Higher Education (US) | 2016-07-14 | — | — | US | disclosed |
| US-4555521-A | Nematicidal 3-substituted-4-phenyl-1,2,5-thiadiazoles | FMC CORPORATION (US) | 1985-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200697-A1 | INHIBITION OF WNT, TGF BETA AND HIPPO SIGNALING PATHWAYS TO TREAT CANCER, ORGAN FIBROSIS AND METABOLIC DISORDERS | WNT1, YAP1, CTNNB1 | KDM4E 2007/4885LMNA 3828/4885GAA 4420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.