Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185886 | 0.87 | PAX8 (0.39) | PAX8BRD4SMN1; SMN2ALDH1A1CREBBP | |
| SCHEMBL15528795 | 0.85 | MAPT (0.36) | PAX8SMN1; SMN2ALDH1A1CYP2C19MAPT | |
| SCHEMBL1099324 | 0.83 | USP30 (0.40) | SMN1; SMN2CYP2C19MAPTAURKARPS6KB1 | |
| SCHEMBL1097623 | 0.83 | MLYCD (0.39) | SMN1; SMN2ALDH1A1CYP2C19MAPTAURKA | |
| SCHEMBL1097539 | 0.81 | F2 (0.36) | SMN1; SMN2ALDH1A1CYP2C19MAPTAURKA | |
| SCHEMBL1098848 | 0.81 | MAPT (0.36) | SMN1; SMN2ALDH1A1CYP2C19MAPTRAB9A | |
| SCHEMBL1794562 | 0.79 | F2 (0.39) | SMN1; SMN2ALDH1A1CYP2C19MAPTAURKA | |
| SCHEMBL380709 | 0.79 | ALDH1A1 (0.57) | PAX8SMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL25886970 | 0.78 | PAX8 (0.43) | PAX8BRD4CREBBPKAT6AKAT5 | |
| SCHEMBL30615320 | 0.77 | PAX8 (0.44) | PAX8BRD4ALDH1A1CREBBPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | US | disclosed |
| US-8153643-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2012-04-10 | — | — | US | disclosed |
| US-20090233924-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233924-A1 | Quinazoline derivatives | AQP1, PGF, F12 | PAX8 794/4885BRD4 266/4885SMN1; SMN2 3491/4885 |
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | AQP1, F12, AQP3 | PAX8 810/4885BRD4 246/4885SMN1; SMN2 3388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.