Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | CCR6 | P51684 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003729 | 0.82 | SIGMAR1 (0.38) | RGS4MAPTNPSR1LMNACACNA1B | |
| SCHEMBL149927 | 0.82 | MAPT (0.53) | RGS4MAPTNPSR1LMNACACNA1B | |
| Ethane SCHEMBL8564354 | 0.80 | MAPT (0.51) | RGS4MAPTNPSR1LMNACACNA1B | |
| SCHEMBL1471680 | 0.77 | MGLL (0.52) | RGS4MAPTNPSR1LMNACACNA1B | |
| SCHEMBL4185573 | 0.75 | AKR1C3 (0.38) | RGS4MAPTNPSR1LMNACACNA1B | |
| SCHEMBL11000171 | 0.74 | AHR (0.43) | RGS4MAPTNPSR1LMNACACNA1B | |
| SCHEMBL4194142 | 0.74 | PGR (0.39) | MAPTNPSR1LMNACACNA1BAPBA1 | |
| SCHEMBL13931143 | 0.73 | MAPT (0.40) | MAPTLMNATDP1ALDH1A1PTGS2 | |
| SCHEMBL1471536 | 0.73 | RGS4 (0.57) | RGS4MAPTNPSR1LMNACACNA1B | |
| SCHEMBL10996746 | 0.73 | MAPT (0.41) | MAPTNPSR1LMNACACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4529736-A | Antidepressant | AMERICAN CYANAMID COMPANY (US) | 1985-07-16 | — | — | US | disclosed |
| EP-0100426-A1 | 3a-(substituted-phenyl)-hexaloctahydro-4,7-alkanoisoindoles | AMERICAN CYANAMID COMPANY (US) | 1984-02-15 | — | — | EP | disclosed |