Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018823 | 0.92 | TOP1 (0.40) | TOP1TOP2ACHEK2NPC1HPGD | |
| SCHEMBL11018211 | 0.91 | CHEK2 (0.47) | TOP1TOP2ACHEK2METAP2METAP1 | |
| SCHEMBL11017857 | 0.86 | ALDH1A1 (0.46) | TOP1TOP2ACHEK2NPC1HPGD | |
| SCHEMBL11018202 | 0.83 | PDE2A (0.43) | TOP1TOP2ACHEK2MAOB | |
| SCHEMBL11018596 | 0.82 | TP53 (0.54) | TOP1TOP2ACHEK2NPC1HPGD | |
| SCHEMBL11021228 | 0.82 | AMY1A (0.54) | CHEK2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL11018206 | 0.82 | CHEK2 (0.61) | CHEK2F2F10PLGPLAU | |
| SCHEMBL10736446 | 0.81 | TOP1 (0.41) | TOP1TOP2ANPC1HPGDRAB9A | |
| SCHEMBL11018042 | 0.81 | CHEK2 (0.48) | TOP1TOP2ACHEK2NPC1HPGD | |
| SCHEMBL11021674 | 0.81 | METAP2 (0.46) | CHEK2NPC1HPGDRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |