Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | SCD | O00767 | 5/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | CFB | P00751 | 3/20 | 0.44 |
| ▸ | FADS1 | O60427 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021893 | 0.91 | ATR (0.44) | ATRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL11020318 | 0.90 | CA12 (0.54) | ATRSCDPKN1PKN2CFB | |
| SCHEMBL11018186 | 0.89 | CYP3A4 (0.48) | ATRSCDPKN1PKN2CFB | |
| SCHEMBL11016115 | 0.89 | CFB (0.47) | ATRPKN1PKN2CFBCHEK2 | |
| SCHEMBL11022217 | 0.89 | ATR (0.53) | ATRNPBWR1SCDPKN1PKN2 | |
| SCHEMBL11018866 | 0.89 | MAPT (0.44) | ATRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL11018077 | 0.87 | CYP2C9 (0.54) | ATRPKN1PKN2CFBCHEK2 | |
| SCHEMBL11021561 | 0.84 | L3MBTL1 (0.47) | ATRPKN1PKN2CFBCHEK2 | |
| SCHEMBL11017639 | 0.84 | MAPT (0.49) | ATRPKN1PKN2CFB | |
| SCHEMBL10580157 | 0.84 | CDK4 (0.47) | CDK4CCNA2CCND1CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | claimed |
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |