Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | OGT | O15294 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021736 | 0.92 | MAPT (0.43) | ATRMAPTALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL11022217 | 0.89 | ATR (0.53) | ATRMAPTMETAP2METAP1PKN1 | |
| SCHEMBL11018866 | 0.89 | MAPT (0.44) | ATRMAPTALDH1A1SMN1; SMN2METAP2 | |
| SCHEMBL11021091 | 0.88 | ATR (0.48) | ATRMAPTALDH1A1SMN1; SMN2METAP2 | |
| SCHEMBL11021240 | 0.86 | MAPT (0.46) | ATRMAPTALDH1A1SMN1; SMN2METAP2 | |
| SCHEMBL11018857 | 0.81 | MAPT (0.44) | ATRMAPTALDH1A1MEN1LMNA | |
| SCHEMBL11022213 | 0.81 | ATR (0.44) | ATRMAPTTRPV4PDE5A | |
| SCHEMBL11021561 | 0.81 | L3MBTL1 (0.47) | ATRMAPTALDH1A1SMN1; SMN2METAP2 | |
| SCHEMBL11021081 | 0.80 | CA12 (0.43) | ATRMAPTCHEK2TRPV4KMT2A | |
| SCHEMBL11018186 | 0.80 | CYP3A4 (0.48) | ATRPKN1PKN2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |