Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020861 | 0.90 | ATM (0.41) | NPC1RAB9ATP53MAPTL3MBTL1 | |
| SCHEMBL11017894 | 0.85 | CHEK2 (0.43) | TDP1POLBNPC1RAB9ATP53 | |
| SCHEMBL11016884 | 0.83 | CHEK2 (0.41) | CHEK2 | |
| SCHEMBL11017084 | 0.82 | ALDH1A1 (0.41) | CHEK2KDM4EALDH1A1HPGD | |
| SCHEMBL10416056 | 0.79 | PDE5A (0.39) | NPC1RAB9ATP53MAPTKDM4E | |
| SCHEMBL11019017 | 0.77 | HPSE (0.42) | POLBTP53MAPTCHEK2ALDH1A1 | |
| SCHEMBL11020728 | 0.76 | AMY1A (0.48) | TDP1POLBNPC1RAB9ATP53 | |
| SCHEMBL11016456 | 0.76 | CHEK2 (0.44) | CHEK2 | |
| SCHEMBL11019649 | 0.76 | RHEB (0.44) | NPC1RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL11017309 | 0.73 | AMY1A (0.40) | MAPTCHEK2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |