Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11022045 | 0.90 | AMY1A (0.47) | AMY1ACHEK2 | |
| SCHEMBL11019903 | 0.90 | AMY1A (0.47) | AMY1ATP53MAPTNPC1RAB9A | |
| SCHEMBL11017268 | 0.88 | CHEK2 (0.47) | AMY1ACHEK2TP53MAPTSMN1; SMN2 | |
| SCHEMBL11020368 | 0.88 | AMY1A (0.46) | AMY1ATP53MAPTNPC1RAB9A | |
| SCHEMBL11017894 | 0.87 | CHEK2 (0.43) | AMY1ACHEK2TDP1POLBTP53 | |
| SCHEMBL11018142 | 0.85 | AMY1A (0.43) | AMY1ATP53MAPTSMN1; SMN2 | |
| SCHEMBL11019266 | 0.84 | AMY1A (0.43) | AMY1ATDP1POLBTP53MAPT | |
| SCHEMBL11019293 | 0.78 | AMY1A (0.49) | AMY1ACHEK2 | |
| SCHEMBL11019017 | 0.78 | HPSE (0.42) | CHEK2POLBTP53MAPTKMT2A | |
| SCHEMBL11016456 | 0.77 | CHEK2 (0.44) | AMY1ACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |