Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017894 | 0.90 | CHEK2 (0.43) | KDM4EALDH1A1SMN1; SMN2NPC1HPGD | |
| SCHEMBL11016456 | 0.89 | CHEK2 (0.44) | MMP2MMP13AMY1A | |
| SCHEMBL11019903 | 0.87 | AMY1A (0.47) | RHEBKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL11020861 | 0.86 | ATM (0.41) | RHEBKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL11016884 | 0.82 | CHEK2 (0.41) | MMP2MMP13AMY1A | |
| SCHEMBL11019266 | 0.80 | AMY1A (0.43) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL11018934 | 0.80 | AMY1A (0.41) | RHEBAMY1APKN1PKN2 | |
| SCHEMBL11017084 | 0.79 | ALDH1A1 (0.41) | KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1170648 | 0.79 | KDM4E (0.61) | RHEBKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL11018142 | 0.78 | AMY1A (0.43) | SMN1; SMN2AMY1AHDAC6MAPTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |