Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017268 | 0.90 | CHEK2 (0.47) | HPSEMAPTCHEK2SMN1; SMN2TP53 | |
| SCHEMBL11018142 | 0.83 | AMY1A (0.43) | HPSEMAPTSMN1; SMN2TP53MAPK10 | |
| SCHEMBL11019903 | 0.79 | AMY1A (0.47) | MAPTALDH1A1SMN1; SMN2HTTTP53 | |
| SCHEMBL11020728 | 0.78 | AMY1A (0.48) | MAPTMEN1KMT2AALDH1A1CHEK2 | |
| SCHEMBL11021667 | 0.78 | AMY1A (0.38) | MAPTMEN1KMT2AALDH1A1CHEK2 | |
| SCHEMBL11022045 | 0.77 | AMY1A (0.47) | CHEK2 | |
| SCHEMBL11020861 | 0.77 | ATM (0.41) | MAPTMEN1KMT2AALDH1A1CHEK2 | |
| SCHEMBL11019171 | 0.77 | TDP1 (0.42) | MAPTMEN1KMT2AALDH1A1CHEK2 | |
| SCHEMBL11019019 | 0.77 | HPSE (0.42) | HPSEMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL11019266 | 0.77 | AMY1A (0.43) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |