Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019646 | 0.93 | MAPT (0.47) | MAPTKDM4EALDH1A1PDE4APDE4B | |
| SCHEMBL11018192 | 0.84 | MAPT (0.48) | MAPTKDM4EALDH1A1PDE4APDE4B | |
| SCHEMBL11018637 | 0.81 | ALDH1A1 (0.44) | MAPTKDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL11020863 | 0.78 | SMN1; SMN2 (0.44) | MAPTKDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL10765896 | 0.77 | ATR (0.48) | MAPTKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL11018196 | 0.77 | CHEK2 (0.51) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11018710 | 0.77 | CA2 (0.44) | KDM4EALDH1A1SMN1; SMN2LMNACA12 | |
| SCHEMBL11018034 | 0.76 | RHEB (0.39) | MAPTKDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL11021552 | 0.76 | L3MBTL1 (0.47) | MAPTKDM4EALDH1A1PDE4APDE4B | |
| SCHEMBL11017972 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1POLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |