Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | XBP1 | P17861 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019903 | 0.88 | AMY1A (0.47) | AMY1AMAPTLMNAHSD17B10KDM4E | |
| SCHEMBL11020728 | 0.84 | AMY1A (0.48) | AMY1AMEN1KMT2AMAPTPOLB | |
| SCHEMBL11022045 | 0.83 | AMY1A (0.47) | AMY1A | |
| SCHEMBL11018142 | 0.83 | AMY1A (0.43) | AMY1AMAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL11020368 | 0.82 | AMY1A (0.46) | AMY1AMAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL11017268 | 0.82 | CHEK2 (0.47) | AMY1AMAPTTP53SMN1; SMN2 | |
| SCHEMBL11019649 | 0.80 | RHEB (0.44) | AMY1AMEN1KMT2AMAPTLMNA | |
| SCHEMBL11019270 | 0.78 | KDM4E (0.45) | MEN1KMT2AMAPTLMNAALOX15 | |
| SCHEMBL11019017 | 0.77 | HPSE (0.42) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL11017894 | 0.76 | CHEK2 (0.43) | AMY1AMEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |