Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017268 | 0.89 | CHEK2 (0.47) | AMY1AMAPTTP53SMN1; SMN2DGAT1 | |
| SCHEMBL11019903 | 0.86 | AMY1A (0.47) | AMY1AMAPTTP53SMN1; SMN2DGAT1 | |
| SCHEMBL11020728 | 0.85 | AMY1A (0.48) | AMY1AMAPTTP53SMN1; SMN2 | |
| SCHEMBL11022045 | 0.84 | AMY1A (0.47) | AMY1A | |
| SCHEMBL11019266 | 0.83 | AMY1A (0.43) | AMY1AMAPTTP53SMN1; SMN2TSHR | |
| SCHEMBL11019017 | 0.83 | HPSE (0.42) | MAPTTP53SMN1; SMN2MAPK10HPSE | |
| SCHEMBL11020368 | 0.82 | AMY1A (0.46) | AMY1AMAPTTP53SMN1; SMN2DGAT1 | |
| SCHEMBL11019649 | 0.78 | RHEB (0.44) | AMY1AMAPTSMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL11018145 | 0.77 | NPC1 (0.45) | TP53SMN1; SMN2ROCK2ROCK1HDAC6 | |
| SCHEMBL11017894 | 0.77 | CHEK2 (0.43) | AMY1AMAPTTP53SMN1; SMN2APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |