Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 9/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019293 | 0.89 | AMY1A (0.49) | AMY1AMETAP2METAP1PKN1PKN2 | |
| SCHEMBL11018934 | 0.80 | AMY1A (0.41) | AMY1AMETAP2METAP1PKN1PKN2 | |
| SCHEMBL11017309 | 0.78 | AMY1A (0.40) | AMY1AKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7278430 | 0.78 | PDE5A (0.39) | AMY1AKDM4EALDH1A1HPGDMETAP2 | |
| SCHEMBL11019017 | 0.78 | HPSE (0.42) | MEN1ALDH1A1MAPTKMT2ACHEK2 | |
| SCHEMBL11021670 | 0.74 | PDE5A (0.38) | KDM4EMEN1ALDH1A1CYP1A2MAPT | |
| SCHEMBL11022213 | 0.73 | ATR (0.44) | MAPT | |
| SCHEMBL11018065 | 0.73 | PDE5A (0.37) | KDM4EMEN1ALDH1A1CYP1A2MAPT | |
| SCHEMBL11021081 | 0.72 | CA12 (0.43) | MAPTKMT2AS1PR1CHEK2 | |
| SCHEMBL11018823 | 0.72 | TOP1 (0.40) | KDM4EALDH1A1CYP1A2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |