Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Tipepidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tipepidine SCHEMBL410090 | 0.89 | NOS3 (0.43) | LMNATSHRALDH1A1KDM4ECASP1 | |
| Tipepidine SCHEMBL30827547 | 0.88 | NOS3 (0.42) | LMNATSHRALDH1A1GAARAB9A | |
| Tipepidine SCHEMBL663025 | 0.82 | KDM4E (0.41) | TP53LMNATSHRALDH1A1KDM4E | |
| Tipepidine SCHEMBL13723968 | 0.74 | OPRM1 (0.35) | TSHRALDH1A1KDM4ECASP1GAA | |
| Tipepidine SCHEMBL28142103 | 0.72 | OPRM1 (0.34) | LMNATSHRALDH1A1GAAMEN1 | |
| SCHEMBL11488710 | 0.68 | SETD7 (0.79) | LMNAALDH1A1MEN1KMT2ASETD7 | |
| SCHEMBL14528192 | 0.68 | CYP2C9 (0.45) | TP53LMNAALDH1A1GAARAB9A | |
| Benzoic Acid SCHEMBL30568378 | 0.67 | HPGDS (0.61) | HPGDSLMNATSHRALDH1A1DAO | |
| SCHEMBL14612383 | 0.64 | GAA (0.76) | LMNATSHRALDH1A1KDM4EGAA | |
| Thiophene Carboxylic Acid SCHEMBL11663065 | 0.64 | DAO (0.86) | HPGDSLMNATSHRALDH1A1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0076515-B1 | RAPIDLY RELEASABLE MICROCAPSULES AND METHOD FOR THE PREPARATION THEREOF | Tanabe Seiyaku Co., Ltd. (JP) | 1985-07-03 | — | — | EP | disclosed |
| EP-0077956-B1 | ENTERIC MICROCAPSULES AND PROCESS FOR THE PREPARATION THEREOF | Tanabe Seiyaku Co., Ltd. (JP) | 1985-07-03 | — | — | EP | disclosed |
| EP-0077956-A1 | Enteric microcapsules and process for the preparation thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1983-05-04 | — | — | EP | disclosed |
| EP-0076515-A1 | Rapidly releasable microcapsules and method for the preparation thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1983-04-13 | — | — | EP | disclosed |