Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 14/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM6A | O15550 | 1/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4B | O94953 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491259 | 0.86 | ELANE (0.59) | KMT2AKDM4EL3MBTL1MEN1NPC1 | |
| SCHEMBL3707206 | 0.80 | ELANE (0.44) | KMT2AKDM4EL3MBTL1MEN1NPC1 | |
| SCHEMBL29443982 | 0.80 | ELANE (0.44) | KMT2AKDM4EL3MBTL1MEN1NPC1 | |
| SCHEMBL28673352 | 0.78 | ELANE (0.49) | KDM4EL3MBTL1ELANEKDM6BKDM6A | |
| SCHEMBL28994902 | 0.78 | ELANE (0.59) | KMT2AKDM4EL3MBTL1MEN1HSP90AA1 | |
| SCHEMBL30069016 | 0.78 | ELANE (0.49) | KDM4EL3MBTL1ELANEKDM6BKDM6A | |
| SCHEMBL11027996 | 0.76 | ELANE (0.48) | KDM4EL3MBTL1NPC1RAB9AELANE | |
| SCHEMBL15902268 | 0.76 | KDM4E (0.47) | KMT2AKDM4EL3MBTL1MEN1NPC1 | |
| SCHEMBL970742 | 0.76 | ALDH1A1 (0.54) | KMT2AKDM4EL3MBTL1MEN1NPC1 | |
| SCHEMBL12146934 | 0.76 | KDM4E (0.46) | KMT2AKDM4EL3MBTL1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12012411-B2 | Viral replication inhibitors | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2024-06-18 | — | — | US | disclosed |
| CN-118139864-A | New compounds | 西特瑞治疗有限公司 | 2024-06-04 | — | — | CN | disclosed |
| US-20210403470-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | WATKINS EDMOND BLAKE (US) | 2021-12-30 | — | — | US | disclosed |
| US-11117893-B2 | Methods for preparation of substituted pyridines and related novel compounds | UNION UNIVERSITY (US) | 2021-09-14 | — | — | US | disclosed |
| US-10927080-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2021-02-23 | — | — | US | disclosed |
| CN-110461849-B | CSF1R inhibitor and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-09-01 | — | — | CN | disclosed |
| US-20200095245-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | UNION UNIVERSITY | 2020-03-26 | — | — | US | disclosed |
| EP-3617192-A1 | VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven K.U. Leuven R&D (BE) | 2020-03-04 | — | — | EP | disclosed |
| US-10550123-B2 | Viral replication inhibitors | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2020-02-04 | — | — | US | disclosed |
| CN-110461849-A | A kind of CSF1R inhibitor and its preparation method and application | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |
| US-20190337954-A1 | VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2019-11-07 | — | — | US | disclosed |
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-10-01 | — | — | US | disclosed |
| EP-2760831-B1 | VIRAL REPLICATION INHIBITORS | UNIV LEUVEN KATH (BE) | 2019-08-07 | — | — | EP | disclosed |
| US-20180258044-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-09-13 | — | — | US | disclosed |
| EP-3344615-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No. 2) Limited (GB) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017037116-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-03-09 | — | — | WO | disclosed |
| EP-2760831-A1 | VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2014-08-06 | — | — | EP | disclosed |
| US-20140213586-A1 | VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2014-07-31 | — | — | US | disclosed |
| WO-2013045516-A1 | VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2013-04-04 | — | — | WO | disclosed |
| US-20120190701-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428026-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | BRD4, BRD3, BRDT | KMT2A 208/4885KDM4E 426/4885L3MBTL1 4684/4885 |
| US-20210403470-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | WEE1, WEE2, THEM6 | KMT2A 2316/4885KDM4E 2177/4885L3MBTL1 4355/4885 |
| US-20140213586-A1 | VIRAL REPLICATION INHIBITORS | EIF2AK2, MAVS, ZC3HAV1 | KMT2A 2425/4885KDM4E 1372/4885L3MBTL1 2136/4885 |
| US-11117893-B2 | Methods for preparation of substituted pyridines and related novel compounds | NNMT, CYP4F3, AGPS | KMT2A 2314/4885KDM4E 2302/4885L3MBTL1 4409/4885 |
| US-20120190701-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | KMT2A 4131/4885KDM4E 3912/4885L3MBTL1 3966/4885 |
| US-20190337954-A1 | VIRAL REPLICATION INHIBITORS | EIF2AK2, MAVS, ZC3HAV1 | KMT2A 2425/4885KDM4E 1372/4885L3MBTL1 2136/4885 |
| US-20200095245-A1 | NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS | WEE1, WEE2, THEM6 | KMT2A 2316/4885KDM4E 2177/4885L3MBTL1 4355/4885 |
| US-20180258044-A1 | PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRDT | KMT2A 208/4885KDM4E 426/4885L3MBTL1 4684/4885 |
| US-10550123-B2 | Viral replication inhibitors | EIF2AK2, MAVS, ZC3HAV1 | KMT2A 2425/4885KDM4E 1372/4885L3MBTL1 2136/4885 |
| US-10927080-B2 | Pyridinone dicarboxamide for use as bromodomain inhibitors | BRD4, BRD3, BRDT | KMT2A 208/4885KDM4E 426/4885L3MBTL1 4684/4885 |
| US-12012411-B2 | Viral replication inhibitors | EIF2AK2, MAVS, ZC3HAV1 | KMT2A 2425/4885KDM4E 1372/4885L3MBTL1 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.