Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249336 | 0.76 | EHMT2 (0.47) | TSHRKMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10378521 | 0.70 | NAPRT (0.39) | P2RX7TSHRNAPRTKMT2AALDH1A1 | |
| SCHEMBL5791332 | 0.69 | — | — | |
| SCHEMBL27487108 | 0.68 | FBP1 (0.47) | TSHRALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL27417893 | 0.68 | MEN1 (0.41) | NAPRTKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL27295548 | 0.67 | RECQL (0.47) | KMT2AALDH1A1SMN1; SMN2MKNK1MKNK2 | |
| SCHEMBL158241 | 0.67 | SIRT1 (0.42) | TSHRKMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28171871 | 0.66 | RAB9A (0.50) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL1594378 | 0.65 | LMNA (0.52) | P2RX7ALDH1A1LMNAMAPTPKM | |
| SCHEMBL1327770 | 0.65 | KMT2A (0.61) | TSHRKMT2AALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101759651-B | 4, 5-diaryl pyrimidine thiourea compound and medical application thereof | SHAANXI NORMAL UNIVERSITY (CN) | 2012-02-22 | — | — | CN | claimed |
| CN-101759651-A | 4, 5-diaryl pyrimidine thiourea compound as well as preparation method and medical application thereof | UNIV SHAANXI NORMAL | 2010-06-30 | — | — | CN | claimed |
| CN-101759651-B | 4, 5-diaryl pyrimidine thiourea compound and medical application thereof | SHAANXI NORMAL UNIVERSITY (CN) | 2012-02-22 | — | — | CN | disclosed |
| CN-101550159-B | A chiral bithioureido derivative containing phosphonate as well as its preparing method and use | UNIV GUIZHOU | 2011-07-27 | — | — | CN | disclosed |
| CN-101759651-A | 4, 5-diaryl pyrimidine thiourea compound as well as preparation method and medical application thereof | UNIV SHAANXI NORMAL | 2010-06-30 | — | — | CN | disclosed |
| CN-101550159-A | A chiral bithioureido derivate containing phosphonate as well as its preparing method and use | UNIV GUIZHOU (CN) | 2009-10-07 | — | — | CN | disclosed |
| EP-0039037-B1 | PYRIMIDYLTHIO-UREAS, MEDICINES CONTAINING THEM AND THEIR USE | Beiersdorf Aktiengesellschaft (DE) | 1985-01-16 | — | — | EP | disclosed |
| EP-0039037-A1 | Pyrimidylthio-ureas, medicines containing them and their use | Beiersdorf Aktiengesellschaft (DE) | 1981-11-04 | — | — | EP | disclosed |